ZAORALOVÁ, Romana, Petr KUGLÍK, Hana FILKOVÁ, Henrieta GREŠLIKOVÁ, Pavel NĚMEC, Alexandra OLTOVÁ, Luděk POUR, Zdeněk ADAM, Andrea KŘIVANOVÁ, Marta KREJČÍ and Roman HÁJEK. Clinical implications of chromosomal aberrations (13q14 and 17p13 deletion, translocation t(4;14) and 1q21 amplification) in patients with relapsed multiple myeloma treated by thalidomide or bortezomib (Velcade). In From cell sorting to plasma cell identification and chromosomal aberrations in multiple myeloma – Application manual. Brno: vydavatelství Masarykovy Univerzity, 2007, p. 12-13. ISBN 978-80-210-4417-3.
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Basic information
Original name Clinical implications of chromosomal aberrations (13q14 and 17p13 deletion, translocation t(4;14) and 1q21 amplification) in patients with relapsed multiple myeloma treated by thalidomide or bortezomib (Velcade)
Name in Czech Klinické důsledky výskytu chromozomálních aberací (delece 13q14 a 17p13, translokace t(4;14) a amplifikaci 1q21) u pacientů s mnohočetným myelomem léčených thalidomodem nebo bortezomibem (Velcade)
Authors ZAORALOVÁ, Romana (203 Czech Republic), Petr KUGLÍK (203 Czech Republic, guarantor), Hana FILKOVÁ (203 Czech Republic), Henrieta GREŠLIKOVÁ (703 Slovakia), Pavel NĚMEC (203 Czech Republic), Alexandra OLTOVÁ (203 Czech Republic), Luděk POUR (203 Czech Republic), Zdeněk ADAM (203 Czech Republic), Andrea KŘIVANOVÁ (203 Czech Republic), Marta KREJČÍ (203 Czech Republic) and Roman HÁJEK (203 Czech Republic).
Edition Brno, From cell sorting to plasma cell identification and chromosomal aberrations in multiple myeloma – Application manual, p. 12-13, 2 pp. 2007.
Publisher vydavatelství Masarykovy Univerzity
Other information
Original language English
Type of outcome Proceedings paper
Field of Study Genetics and molecular biology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/07:00019107
Organization unit Faculty of Science
ISBN 978-80-210-4417-3
Keywords in English Multiple myeloma; CKS1B amplification; RB deletion; p53 deletion; t(4;14); cIg FISH
Tags 14), cIg FISH, CKS1B amplification, multiple myeloma, p53 deletion, RB deletion, t(4
Tags International impact
Changed by Changed by: doc. RNDr. Petr Kuglík, CSc., učo 1881. Changed: 5/11/2007 09:29.
Abstract
The aim of the work was: 1) To study the incidence of the chromosomal aberrations known as adverse prognostic factors in MM - deletion of 13q14 (RB1), deletion of 17p13 (p53), amplification of 1q21 (CKS1B) and translocation t(4;14) in a group of 40 patients with relapsed MM. 2) To compare the prognostic and predictive significance of these unfavorable chromosomal aberrations in patients with relapsed MM treated with thalidomide or bortezomib (Velcade) based regimens.
Abstract (in Czech)
V práci je shrnutí našich současných poznatků o vlivu cytogenetických negativních prognostických markerů u nemocných mnohočetným myelomem léčených novými léky.
Links
LC06027, research and development projectName: Univerzitní výzkumné centrum - Česká myelomová skupina (Acronym: LC MGUS)
Investor: Ministry of Education, Youth and Sports of the CR, University Research Centre - Czech Myeloma Group
MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
NR9317, research and development projectName: Prognostický význam klonálních chromosomových aberací při použití nových léčebných metod u mnohočetného myelomu
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