ŠPINAR, Jindřich, Ondřej LUDKA, Ladislav DUŠEK, Lenka VÍTOVCOVÁ, Dorota SOBOTOVÁ, Lenka ŠPINAROVÁ, Josef TOMANDL and Jiří VÍTOVEC. Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated by hemolysis. Kidney and Blood Pressure Research. Switzerland: S. Karger AG, 2007, vol. 30, No 5, p. 347-357. ISSN 1420-4096.
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Basic information
Original name Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated by hemolysis
Name in Czech Neurohumorální aktivita, srdeční selhání a prognóza u nemocných v konečném stadiu renálního onemocnění léčených hemodialýzou
Authors ŠPINAR, Jindřich (203 Czech Republic, guarantor, belonging to the institution), Ondřej LUDKA (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Lenka VÍTOVCOVÁ (203 Czech Republic), Dorota SOBOTOVÁ (203 Czech Republic), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution) and Jiří VÍTOVEC (203 Czech Republic, belonging to the institution).
Edition Kidney and Blood Pressure Research, Switzerland, S. Karger AG, 2007, 1420-4096.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.092
RIV identification code RIV/00216224:14110/07:00032474
Organization unit Faculty of Medicine
UT WoS 000249306000012
Keywords in English NT-proBNP; big endothelin; heart failure; renal disease
Tags Big endothelin, Heart failure, NT-proBNP, renal disease
Tags International impact, Reviewed
Changed by Changed by: doc. RNDr. Josef Tomandl, Ph.D., učo 47. Changed: 6/6/2012 08:44.
Abstract
Chronic renal failure treated by regular hemodialysis is frequently accompanied by chronic heart failure; the mortality of both is high. Aim: To evaluate the role of markers of neurohumoral activation for the prognosis of patients treated with regular dialysis. Patients: 99 patients with end-stage renal disease were followed up for 3 years. Methods: Clinical evaluation, echocardiography, biochemistry including NT-proBNP and big endothelin (Big-ET). Results: The incidence of heart failure was 97% and the 3-year mortality was 50%. The sensitivity of NT-proBNP and Big-ET level for the prediction of death was 0.712 and 0.824, respectively, and specificity 0.642 and 0.695, respectively. The cut-off points were NT-proBNP 2,000 pg/ml and Big-ET 1.55 pmol/l. Neither NT-proBNP nor Big-ET could be incorporated in the multivariate model for overall survival, which means that although both parameters significantly influenced overall survival as single risk factors, they were not effective in competition with the other significant predictors. Conclusion: Overall survival seems to be influenced namely by age, hemoglobin, left atrium diameter or pulmonary congestion class on chest X-ray, while probability of early risk was associated with Big-ET, history of diabetes mellitus, C-reactive protein, uric acid and hemoglobin. The only intersection of the models is hemoglobin as a thoroughly significant predictor.
Abstract (in Czech)
Neurohumorální aktivita, srdeční selhání a prognóza u nemocných v konečném stadiu renálního onemocnění léčených hemodialýzou
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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