ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC
FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS
STEM CELL TRANSPLANTATION

D 2007

ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

GREŠLIKOVÁ, Henrieta, Hana FILKOVÁ, Petr KUGLÍK, Alexandra OLTOVÁ, Luděk POUR et. al.

Basic information

Original name

ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

Name in Czech

Asociácia chromozómových zmien a štantdardných prognostických faktorov u pacientov s mnohopočetným myelomom liečených autológnou transplantáciou

Authors

GREŠLIKOVÁ, Henrieta (703 Slovakia), Hana FILKOVÁ (203 Czech Republic), Petr KUGLÍK (203 Czech Republic, guarantor), Alexandra OLTOVÁ (203 Czech Republic), Luděk POUR (203 Czech Republic), Zdeněk ADAM (203 Czech Republic), Andrea KŘIVANOVÁ (203 Czech Republic), Marta KREJČÍ (203 Czech Republic), Jana SMEJKALOVÁ (203 Czech Republic) and Roman HÁJEK (203 Czech Republic)

Edition

Volume 92, supplement no.1. Pavia, Italy, Hematologica/The Hematology Journal, p. 497-497, 1 pp. 2007

Publisher

Ferrata-Storti Foundation

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

Genetics and molecular biology

Country of publisher

Italy

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.516

RIV identification code

RIV/00216224:14110/07:00019110

Organization unit

Faculty of Medicine

ISSN

UT WoS

000247176901599

Keywords in English

Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion

Abstract

ORIG CZ

V originále

Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. Aims To determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17.5 months, median age 57 years (39-67), DS stadium: stage I 7.1%, II 24.3%, III 68.6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78.5% including 13% CR, 27% VGPR and 38.5% PR. Median of time to progression (TTP) was 17.5 (0.4-41.4) months. Median of overall survival (OS) was 22.9 (0.4-48.5) months. The aberration of the chromosome 13 was found in 58% (40/69), IGH rearrangements in 57% (37/65), t(11;14) in 36% (13/37), t(4;14) in 33% (12/37) and deletion of 17p13 in 50% (23/46) pts. We have correlated standard prognostic factors (MIG, LD, B2M, Hb, CRP, Ca, albumin), TTP, progression free survival (PFS), duration of response (DOR) and OS with the occurrence of the mentioned aberrations. Higher CRP, lower albumin and lower Ca concentrations were detected in patients with aberration of chromosome 13. Higher Ca concentration (p = 0.042) was found in patient with t(11;14). We have observed trend for shorter TTP in patients with deletion of 17p13 and then in pts without this deletion (18.5 vs.21.9 months; p=0.287). As for this aberration we have found no significant difference when compared incidence of each chromosomal aberration for TTP, DOR, PFS and OS. Summary/Conclusion We have analysed data of the homogenous group of patients undergoing autologous transplantation in the CMG trial of Czech Myeloma Group. Based on the results we conclude that patients with deletion of 13q14 have higher CRP, lower albumin and lower Ca concentration. This analysis will be extended for all centres of CMG 2002.

In Czech

Práce pojednává o význame chromozomových zmien a ich vztahu k štandardným prognostickým faktorom u pacientov s mnohopočetným myelomem léčených konvenčnou chemoterapiou a následnou autológnou transplantáciou.

Links

NR8183, research and development project

Name: Molekulárně-cytogenetická analýza značených plazmatických buněk a prognostický význam klonálních chromosomových aberací u mnohočetného myelomu

Citovat

GREŠLIKOVÁ, Henrieta, Hana FILKOVÁ, Petr KUGLÍK, Alexandra OLTOVÁ, Luděk POUR, Zdeněk ADAM, Andrea KŘIVANOVÁ, Marta KREJČÍ, Jana SMEJKALOVÁ and Roman HÁJEK. ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION. In Hematologica/The Hematology Journal. Volume 92, supplement no.1. Pavia, Italy: Ferrata-Storti Foundation, 2007, p. 497-497. ISSN 0390-6078.

@inproceedings{727209,
   author = {Grešliková, Henrieta and Filková, Hana and Kuglík, Petr and Oltová, Alexandra and Pour, Luděk and Adam, Zdeněk and Křivanová, Andrea and Krejčí, Marta and Smejkalová, Jana and Hájek, Roman},
   address = {Pavia, Italy},
   booktitle = {Hematologica/The Hematology Journal},
   edition = {Volume 92, supplement no.1},
   keywords = {Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion},
   language = {eng},
   location = {Pavia, Italy},
   pages = {497-497},
   publisher = {Ferrata-Storti Foundation},
   title = {ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION},
   year = {2007}
}

TY  - JOUR
ID  - 727209
AU  - Grešliková, Henrieta - Filková, Hana - Kuglík, Petr - Oltová, Alexandra - Pour, Luděk - Adam, Zdeněk - Křivanová, Andrea - Krejčí, Marta - Smejkalová, Jana - Hájek, Roman
PY  - 2007
TI  - ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
PB  - Ferrata-Storti Foundation
CY  - Pavia, Italy
KW  - Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion
N2  - Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. Aims To determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17.5 months, median age 57 years (39-67), DS stadium: stage I 7.1%, II 24.3%, III 68.6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78.5% including 13% CR, 27% VGPR and 38.5% PR. Median of time to progression (TTP) was 17.5 (0.4-41.4) months. Median of overall survival (OS) was 22.9 (0.4-48.5) months. The aberration of the chromosome 13 was found in 58% (40/69), IGH rearrangements in 57% (37/65), t(11;14) in 36% (13/37), t(4;14) in 33% (12/37) and deletion of 17p13 in 50% (23/46) pts. We have correlated standard prognostic factors (MIG, LD, B2M, Hb, CRP, Ca, albumin), TTP, progression free survival (PFS), duration of response (DOR) and OS with the occurrence of the mentioned aberrations. Higher CRP, lower albumin and lower Ca concentrations were detected in patients with aberration of chromosome 13. Higher Ca concentration (p = 0.042) was found in patient with t(11;14). We have observed trend for shorter TTP in patients with deletion of 17p13 and then in pts without this deletion (18.5 vs.21.9 months; p=0.287). As for this aberration we have found no significant difference when compared incidence of each chromosomal aberration for TTP, DOR, PFS and OS. Summary/Conclusion We have analysed data of the homogenous group of patients undergoing autologous transplantation in the CMG trial of Czech Myeloma Group. Based on the results we conclude that patients with deletion of 13q14 have higher CRP, lower albumin and lower Ca concentration. This analysis will be extended for all centres of CMG 2002.
ER  -

GREŠLIKOVÁ, Henrieta, Hana FILKOVÁ, Petr KUGLÍK, Alexandra OLTOVÁ, Luděk POUR, Zdeněk ADAM, Andrea KŘIVANOVÁ, Marta KREJČÍ, Jana SMEJKALOVÁ and Roman HÁJEK. ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION. In \textit{Hematologica/The Hematology Journal}. Volume 92, supplement no.1. Pavia, Italy: Ferrata-Storti Foundation, 2007, p.~497-497. ISSN~0390-6078.

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