Detailed Information on Publication Record
2007
Molecular dissection of Rad52 mediator activity
KREJČÍ, LumírBasic information
Original name
Molecular dissection of Rad52 mediator activity
Name in Czech
Molekularní charakterizace mediátorové aktivity proteinu Rad52
Authors
KREJČÍ, Lumír (203 Czech Republic, guarantor)
Edition
Heidelberg, 2007
Publisher
EMBO
Other information
Language
English
Type of outcome
Audiovizuální tvorba
Field of Study
10600 1.6 Biological sciences
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14310/07:00022863
Organization unit
Faculty of Science
Keywords in English
recombination; repair; cancer; Rad52; BRCA2
Tags
Tags
International impact
Změněno: 31/3/2010 11:32, doc. Mgr. Lumír Krejčí, Ph.D.
V originále
DNA strand break repair by HR is mediated by genes of the RAD52 epistasis group. Rad52 protein plays central role in this process. It binds and anneals complementary ssDNA, self-associate to form multimeric rings, interacts with Rad51, and promotes nucleation of Rad51 onto ssDNA. Here, we show that Rad52 competes with Srs2 anti-recombinase in mediating Rad51-catalyzed strand exchange reaction through common interaction site on Rad51. The molecular mechanism of Rad52 function in homologous recombination together with the role of postranslational modification (SUMO-ylation) is discussed.
In Czech
V rámci této práce jsou prezentovány naše nové poznatky o proteinu Rad52 jeho kompetici s anti-rekombinčním proteinem Srs a regulaci pomocí kovaletní modifikace Smt3 peptidem.
Links
LC06030, research and development project |
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ME 888, research and development project |
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MSM0021622413, plan (intention) |
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