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@misc{727349,
author = {Krejčí, Lumír},
address = {Heidelberg},
keywords = {recombination; repair; DNA; cancer; Rad52; Srs2; mediator activity; SUMOylation},
language = {eng},
location = {Heidelberg},
publisher = {EMBO/HHMI},
title = {Molecular understanding of DSB repair-Mediator proteins},
url = {http://www.embo.org/yip/hhmi_meeting07.html},
year = {2007}
}
TY - GEN
ID - 727349
AU - Krejčí, Lumír
PY - 2007
TI - Molecular understanding of DSB repair-Mediator proteins
PB - EMBO/HHMI
CY - Heidelberg
KW - recombination
KW - repair
KW - DNA
KW - cancer
KW - Rad52
KW - Srs2
KW - mediator activity
KW - SUMOylation
UR - http://www.embo.org/yip/hhmi_meeting07.html
L2 - http://www.embo.org/yip/hhmi_meeting07.html
N2 - DNA strand break repair by HR is mediated by genes of the RAD52 epistasis group. Rad52 protein plays central role in this process. It binds and anneals complementary ssDNA, self-associate to form multimeric rings, interacts with Rad51, and promotes nucleation of Rad51 onto ssDNA. Here, we show that Rad52 competes with Srs2 anti-recombinase in mediating Rad51-catalyzed strand exchange reaction through common interaction site on Rad51. The molecular mechanism of Rad52 function in homologous recombination together with the role of postranslational modification (SUMO-ylation) is discussed.
ER -
KREJČÍ, Lumír. \textit{Molecular understanding of DSB repair-Mediator proteins}. Heidelberg: EMBO/HHMI, 2007.
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