A 2007

Genetic Recombination & Genome Rearrangements

KREJČÍ, Lumír

Basic information

Original name

Genetic Recombination & Genome Rearrangements

Name in Czech

Genetická rekombinace a přeuspořádání genomu

Authors

KREJČÍ, Lumír (203 Czech Republic, guarantor)

Edition

Snowmass, 2007

Publisher

FASEB

Other information

Language

English

Type of outcome

Audiovizuální tvorba

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

RIV identification code

RIV/00216224:14310/07:00022865

Organization unit

Faculty of Science

Keywords in English

recombination; DNA repair; rearrangements; genome

Tags

Tags

International impact
Změněno: 31/3/2010 11:31, doc. Mgr. Lumír Krejčí, Ph.D.

Abstract

ORIG CZ

V originále

Homologous recombination (HR) represents an important means for the repair of chromosome breaks induced by exogenous agents (e.g. ionizing radiation) or that arise endogenously (e.g. replication of a damaged DNA template). Furthermore, cells have to rely on homologous recombination to rescue stalled replication forks and hence prevent fork demise. If not processed properly, DSBs can lead to chromosomal aberrations and rearrangements, which then give rise to strong mutator and cancer phenotypes. DNA strand break repair by HR is mediated by genes of the RAD52 epistasis group. Rad52 protein plays central role in this process. Here, we show that Rad52 competes with Srs2 anti-recombinase in mediating Rad51-catalyzed strand exchange reaction through common interaction site on Rad51. The molecular mechanism of Rad52 function in homologous recombination together with the role of postranslational modification (SUMO-ylation) is discussed.

In Czech

V tomto přispěvku je diskutována úloha homologní rekombinace při opravě dvouřetezcových zlomů v DNA.

Links

LC06030, research and development project
Name: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
ME 888, research and development project
Name: Srs2 protein a jeho multifunkční úloha při rekombinančních /opravných procesech
Investor: Ministry of Education, Youth and Sports of the CR, Srs2 protein and its multi-functional role in rekombination/repair processes
MSM0021622413, plan (intention)
Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment