High affinity lectins from human opportunistic pathogens: structure/function studies

WIMMEROVÁ, Michaela, Emilie LAMEIGNERE, Lenka MALINOVSKÁ, Charles SABIN, Jan ADAM, Martina POKORNÁ, Annabelle VARROT, Edward P. MITCHELL and Anne IMBERTY. High affinity lectins from human opportunistic pathogens: structure/function studies. In XIX International Symposium on Glycoconjugates. Cairns, Australie: IGO, 2007, p. 56-56.

Basic information

Original name

High affinity lectins from human opportunistic pathogens: structure/function studies

Name in Czech

Vysokoafinitní lektiny z lidských patogenů: strukturně funkční studie

Authors

WIMMEROVÁ, Michaela (203 Czech Republic, guarantor), Emilie LAMEIGNERE (250 France), Lenka MALINOVSKÁ (203 Czech Republic), Charles SABIN (250 France), Jan ADAM (203 Czech Republic), Martina POKORNÁ (203 Czech Republic), Annabelle VARROT (250 France), Edward P. MITCHELL (826 United Kingdom of Great Britain and Northern Ireland) and Anne IMBERTY (250 France)

Edition

Cairns, Australie, XIX International Symposium on Glycoconjugates, p. 56-56, 1 pp. 2007

Publisher

IGO

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Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Australia

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/07:00020582

Organization unit

Faculty of Science

Keywords in English

lectin; pathogen; x-ray structure; calorimetry

Tags

calorimetry, lectin, pathogen, X-RAY STRUCTURE

Tags

International impact

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Abstract

V originále

The complementary techniques of binding experiments, isothermal titration microcalorimetry, surface plasmon resonance and high resolution X-ray crystallography were used to decipher the thermodynamical and structural basis for the unusually high affinity binding of these lectins to their host carbohydrates. In addition, site-directed mutagenesis in combination with structural and functional studies was used to understand the roles of particular amino acids in the fine definition of sugar specificity and preference.

In Czech

Vysokoafinitní lektiny z lidských patogenů: strukturně funkční studie

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Links

GA303/06/0570, research and development project	Name: Strukturně-funkční studie lektinů a adhezinů patogenních mikroorganismů Investor: Czech Science Foundation, Structure-function studies on lectins and adhesins from microbial patogens
LC06030, research and development project	Name: Biomolekulární centrum Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)	Name: Proteiny v metabolismu a při interakci organismů s prostředím Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment