KAŇKOVÁ, Kateřina. Diabetic threesome (hyperglycemia, renal function and nutrition) and advanced glycation end products: evidence for the multiple-hit agent? Proceedings of the Nutrition Society. Cambridge, United Kingdom: Cambridge University Press, 2008, vol. 67, No 1, p. 60-74. ISSN 0029-6651.
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Basic information
Original name Diabetic threesome (hyperglycemia, renal function and nutrition) and advanced glycation end products: evidence for the multiple-hit agent?
Name in Czech Diabetic threesome (hyperglycemia, renal function and nutrition) and advanced glycation end products: evidence for the multiple-hit agent?
Authors KAŇKOVÁ, Kateřina (203 Czech Republic, guarantor).
Edition Proceedings of the Nutrition Society, Cambridge, United Kingdom, Cambridge University Press, 2008, 0029-6651.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30202 Endocrinology and metabolism
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.981
RIV identification code RIV/00216224:14110/08:00024130
Organization unit Faculty of Medicine
UT WoS 000253375200008
Keywords in English AGEs; diabetes mellitus; diabetic nephropathy; fructosamine 3 kinase; glycation; glyoxalase; nutrigenetics; RAGE
Tags AGEs, diabetes mellitus, diabetic nephropathy, fructosamine 3 kinase, glycation, glyoxalase, nutrigenetics, RAGE
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Kateřina Kaňková, Ph.D., učo 2524. Changed: 22/6/2009 09:44.
Abstract
Complex chemical processes called non-enzymatic glycation operating in vivo and analogical chemical interactions between sugars and proteins occurring during thermal processing of food (know se Maillard reaction) are one of the interesting examples of potentially harmful interaction between nutrition and disease. Non-enzymatic glycation comprise a series of reactions between sugars, alpha-oxoaldehydes and other sugar derivatives and amino groups of amino acids, peptides and proteins leading to the formation of heterogeneous moieties collectively called Advanced Glycation End-products (AGEs). AGEs possess a wide range of chemical and biological properties and play a role in diabetes-related pathology as wells as in several other diseases. Diabetes is, nevertheless, of main interest for several reasons: (i) chronic hyperglycemia feeds the substrates for the extra- as well as intracellular glycation, (ii) hyperglycaemia-induced oxidative stress accelerates AGE formation in the process of glycoxidation, (iii) AGE-modified proteins are subjects of rapid intracellular proteolytic degradation releasing free AGE-adducts into the circulation where they can bind to several pro-inflammatory receptors, especially Receptor of AGEs (RAGE), and, finally, (iv) kidneys, which are principally involved in the excretion of free AGE-adducts, might be damaged by diabetic nephropathy and this further enhances AGE-toxicity because of diminished AGE clearance. Increased dietary intake of AGEs in highly processed foods might represent an additional, exogenous, metabolic burden on top of those already present endogenously in diabetics. Finally, interindividual genetic and functional variability in genes encoding enzymes and receptors involved in either formation or degradation of AGEs could have a significant pathogenic, nutrigenomic and nutrigenetic consequences.
Abstract (in Czech)
Complex chemical processes called non-enzymatic glycation operating in vivo and analogical chemical interactions between sugars and proteins occurring during thermal processing of food (know se Maillard reaction) are one of the interesting examples of potentially harmful interaction between nutrition and disease. Non-enzymatic glycation comprise a series of reactions between sugars, alpha-oxoaldehydes and other sugar derivatives and amino groups of amino acids, peptides and proteins leading to the formation of heterogeneous moieties collectively called Advanced Glycation End-products (AGEs). AGEs possess a wide range of chemical and biological properties and play a role in diabetes-related pathology as wells as in several other diseases. Diabetes is, nevertheless, of main interest for several reasons: (i) chronic hyperglycemia feeds the substrates for the extra- as well as intracellular glycation, (ii) hyperglycaemia-induced oxidative stress accelerates AGE formation in the process of glycoxidation, (iii) AGE-modified proteins are subjects of rapid intracellular proteolytic degradation releasing free AGE-adducts into the circulation where they can bind to several pro-inflammatory receptors, especially Receptor of AGEs (RAGE), and, finally, (iv) kidneys, which are principally involved in the excretion of free AGE-adducts, might be damaged by diabetic nephropathy and this further enhances AGE-toxicity because of diminished AGE clearance. Increased dietary intake of AGEs in highly processed foods might represent an additional, exogenous, metabolic burden on top of those already present endogenously in diabetics. Finally, interindividual genetic and functional variability in genes encoding enzymes and receptors involved in either formation or degradation of AGEs could have a significant pathogenic, nutrigenomic and nutrigenetic consequences.
Links
KJB501620601, research and development projectName: Funkční analýza rizikového haplotypu RAGE genu a jeho role v patogenezi hyperglykemií indukovaných změn
Investor: Academy of Sciences of the Czech Republic, Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology
NR9443, research and development projectName: Genetická variabilita enzymů pentózového cyklu jako faktor modulující nástup a progresi diabetické nefropatie
Investor: Ministry of Health of the CR, Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy
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