| BRYJA, Vítězslav, Lukáš ČAJÁNEK, A. GRAHN and G. SCHULTE. Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation. Acta Physiologica. Oxford: Blackwell Publishing, 2007, vol. 190, No 1, p. 53-59. ISSN 1748-1708. |
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@article{745009,
author = {Bryja, Vítězslav and Čajánek, Lukáš and Grahn, A. and Schulte, G.},
article_location = {Oxford},
article_number = {1},
keywords = {beta-catenin; clathrin-mediated endocytosis; desensitization},
language = {eng},
issn = {1748-1708},
journal = {Acta Physiologica},
title = {Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation},
volume = {190},
year = {2007}
}
TY - JOUR
ID - 745009
AU - Bryja, Vítězslav - Čajánek, Lukáš - Grahn, A. - Schulte, G.
PY - 2007
TI - Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation
JF - Acta Physiologica
VL - 190
IS - 1
SP - 53-59
EP - 53-59
PB - Blackwell Publishing
SN - 17481708
KW - beta-catenin
KW - clathrin-mediated endocytosis
KW - desensitization
N2 - We investigated the effects of endocytosis inhibition on Frizzled4-green fluorescent protein (FZD4-GFP) localization, dishevelled levels and Wnt-3a signalling to beta -catenin. Hyperosmotic sucrose and K+ depletion increased the membrane localization of FZD4-GFP, and in parallel triggered fast (1–2 h) and almost complete (approx. 95%) degradation of endogenous dishevelled, which further prevented canonical signalling by Wnt-3a to beta-catenin. The data provide evidence for a molecular mechanism that could be a basis for a novel negative feedback loop within the Wnt/Frizzled pathway depending on dishevelled degradation.
ER -
BRYJA, Vítězslav, Lukáš ČAJÁNEK, A. GRAHN and G. SCHULTE. Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation. \textit{Acta Physiologica}. Oxford: Blackwell Publishing, 2007, vol.~190, No~1, p.~53-59. ISSN~1748-1708.
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