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@article{745010,
author = {Bryja, Vítězslav and Gradl, D. and Schambony, A. and Arenas, E. and Schulte, G.},
article_number = {16},
keywords = {canonical Wnt signaling; dishevelled; Frizzled},
language = {eng},
issn = {1091-6490},
journal = {Proceedings of the National Academy of Sciences of the U.S.A.},
title = {beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo},
volume = {104},
year = {2007}
}
TY - JOUR
ID - 745010
AU - Bryja, Vítězslav - Gradl, D. - Schambony, A. - Arenas, E. - Schulte, G.
PY - 2007
TI - beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo
JF - Proceedings of the National Academy of Sciences of the U.S.A.
VL - 104
IS - 16
SP - 6690-6695
EP - 6690-6695
SN - 10916490
KW - canonical Wnt signaling
KW - dishevelled
KW - Frizzled
N2 - The phosphoprotein dishevelled (Dvl) is an integral part of Wnt signaling and has recently been shown to interact with the multifunctional scaffolding protein beta-arrestin. MEFs lacking beta-arrestins were able to phosphorylate Lrp6 in response to Wnt-3a, but decreased the activation of Dvl and blocked beta-catenin signaling. Furthermore, treatment of Xenopus laevis embryos with beta-arrestin morpholinos reduced the activation of endogenous beta-catenin, decreased the expression of the beta-catenin target gene, Xnr3, and blocked axis duplication induced by X-Wnt-8, and other molecules. Thus, our results identify beta-arrestin as a necessary component for Wnt/ beta-catenin signaling.
ER -
BRYJA, Vítězslav, D. GRADL, A. SCHAMBONY, E. ARENAS and G. SCHULTE. beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. \textit{Proceedings of the National Academy of Sciences of the U.S.A.}. 2007, vol.~104, No~16, p.~6690-6695. ISSN~1091-6490.
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