Colon carcinoma and the possible significance of T-cell
population, including FOXP3-positive lymphocytes

D 2007

Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes

GARAJOVA, Ingrid, Pavel FABIAN, Rudolf NENUTIL, Ilona KOCÁKOVÁ, Peter GRELL et. al.

Basic information

Original name

Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes

Name in Czech

Nádory tlustého střeva a možný význam populace T-buněk, včetně FOXP3-pozitivních lymfocytů

Authors

GARAJOVA, Ingrid, Pavel FABIAN, Rudolf NENUTIL, Ilona KOCÁKOVÁ, Peter GRELL, Zina HANZELKOVÁ, Rostislav VYZULA and Marek SVOBODA

Edition

2007. vyd. Columbia, USA, Proceedings of the American Association for Cancer Research, p. 133-133, 1 pp. 2007

Publisher

American Association for Cancer Reasearch, Inc., Philadelphia, USA

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

ISSN

Keywords in English

colon carcinoma;T-cell lymphocytes;FOXP3

Abstract

ORIG CZ

V originále

Tumor-infiltrating lymphocytes (TIL) of colon carcinoma (CC) include also cytotoxic T-cells that are generally considered as prognostically favourable because of their ability to exert anti-tumor immunity. As progression of CC occurs, the question arises whether the CC microenvironment may have some suppressive capabilities. We were interested if a recently discovered subgroup of T-cells, namely regulatory T-cells (TREG, CD4+ CD25+ FOXP3+), which are able to functionally suppress immune responses and are supposed to lead to tumor progression, makes part of TIL of CC. We used immunohistochemical staining to detect lymphocytes co-expressing CD4+ and FOXP3+ in 44 cases of CC primary tumors, using formalin-fixed and paraffin-embedded sections, and commercially available monoclonal antibodies. We were first indeed to show the occurence of FOXP3+ TREG lymphocytes in CC. What we found interesting in futher studies was the localization of FOXP3+ cells. We observed them in stroma, within the epitelium, but above all they formed invasive fragment between cancer and non-cancer tissue. This localization is very suspicious to play a role in local immune system, although to explain this fact there are futher experiments undergoing in our laboratory. Investigations, in fact, are in progress on: (i) differences in TREG distribution between left/right side-localized CC, (ii) differences in TREG distribution among CC in clinical stage I-IV, (iii) TREG behaviour in cases asssociated with microsatelite instability, which is known to have more favourable clinical outcome. This project is supported by Internal Grant Agency, Ministry of Health, Czech Republic. No.: NR/9076-4.

In Czech

Publikace je pouze v aglickém jazyce.

Links

NR9076, research and development project

Name: Genomické profilování v predikci odpovědi na chemoradioterapii u pacientů s lokálně pokročilým karcinomem konečníku

Citovat

GARAJOVA, Ingrid, Pavel FABIAN, Rudolf NENUTIL, Ilona KOCÁKOVÁ, Peter GRELL, Zina HANZELKOVÁ, Rostislav VYZULA and Marek SVOBODA. Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes. In Proceedings of the American Association for Cancer Research. 2007th ed. Columbia, USA: American Association for Cancer Reasearch, Inc., Philadelphia, USA, 2007, p. 133-133. ISSN 0197-016X.

@inproceedings{746223,
   author = {Garajova, Ingrid and Fabian, Pavel and Nenutil, Rudolf and Kocáková, Ilona and Grell, Peter and Hanzelková, Zina and Vyzula, Rostislav and Svoboda, Marek},
   address = {Columbia, USA},
   booktitle = {Proceedings of the American Association for Cancer Research},
   edition = {2007},
   keywords = {colon carcinoma;T-cell lymphocytes;FOXP3},
   language = {eng},
   location = {Columbia, USA},
   pages = {133-133},
   publisher = {American Association for Cancer Reasearch, Inc., Philadelphia, USA},
   title = {Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes},
   year = {2007}
}

TY  - JOUR
ID  - 746223
AU  - Garajova, Ingrid - Fabian, Pavel - Nenutil, Rudolf - Kocáková, Ilona - Grell, Peter - Hanzelková, Zina - Vyzula, Rostislav - Svoboda, Marek
PY  - 2007
TI  - Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes
PB  - American Association for Cancer Reasearch, Inc., Philadelphia, USA
CY  - Columbia, USA
KW  - colon carcinoma;T-cell lymphocytes;FOXP3
N2  - Tumor-infiltrating lymphocytes (TIL) of colon carcinoma (CC) include also cytotoxic T-cells that are generally considered as prognostically favourable because of their ability to exert anti-tumor immunity. As progression of CC occurs, the question arises whether the CC microenvironment may have some suppressive capabilities. We were interested if a recently discovered subgroup of T-cells, namely regulatory T-cells (TREG, CD4+ CD25+ FOXP3+), which are able to functionally suppress immune responses and are supposed to lead to tumor progression, makes part of TIL of CC. We used immunohistochemical staining to detect lymphocytes co-expressing CD4+ and FOXP3+ in 44 cases of CC primary tumors, using formalin-fixed and paraffin-embedded sections, and commercially available monoclonal antibodies. We were first indeed to show the occurence of FOXP3+ TREG lymphocytes in CC. What we found interesting in futher studies was the localization of FOXP3+ cells. We observed them in stroma, within the epitelium, but above all they formed invasive fragment between cancer and non-cancer tissue. This localization is very suspicious to play a role in local immune system, although to explain this fact there are futher experiments undergoing in our laboratory. Investigations, in fact, are in progress on: (i) differences in TREG distribution between left/right side-localized CC, (ii) differences in TREG distribution among CC in clinical stage I-IV, (iii) TREG behaviour in cases asssociated with microsatelite instability, which is known to have more favourable clinical outcome. This project is supported by Internal Grant Agency, Ministry of Health, Czech Republic. No.: NR/9076-4.
ER  -

GARAJOVA, Ingrid, Pavel FABIAN, Rudolf NENUTIL, Ilona KOCÁKOVÁ, Peter GRELL, Zina HANZELKOVÁ, Rostislav VYZULA and Marek SVOBODA. Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes. In \textit{Proceedings of the American Association for Cancer Research}. 2007th ed. Columbia, USA: American Association for Cancer Reasearch, Inc., Philadelphia, USA, 2007, p.~133-133. ISSN~0197-016X.

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