Immunohistochemical evidence for down-regulation of cannabinoid CB1 receptors in the rat mesencephalon after self-administration of methamphetamine

SVÍŽENSKÁ, Ivana, Petr DUBOVÝ, Ilona KLUSÁKOVÁ, Alexandra ŠULCOVÁ and Jana KUČEROVÁ. Immunohistochemical evidence for down-regulation of cannabinoid CB1 receptors in the rat mesencephalon after self-administration of methamphetamine. In 41st International Congress of Slovak Anatomical Society and 44th Lojda Symposium on Histochemistry "Progress in Basic, Applied and Diagnostic Histochemistry". 2007.

Basic information

Original name

Immunohistochemical evidence for down-regulation of cannabinoid CB1 receptors in the rat mesencephalon after self-administration of methamphetamine

Name in Czech

Imunohistochemický důkaz pro snížení tvorby kanabinoidních receptorů CB1 v mesencephalu potkana po

Authors

SVÍŽENSKÁ, Ivana, Petr DUBOVÝ, Ilona KLUSÁKOVÁ, Alexandra ŠULCOVÁ and Jana KUČEROVÁ

Edition

41st International Congress of Slovak Anatomical Society and 44th Lojda Symposium on Histochemistry "Progress in Basic, Applied and Diagnostic Histochemistry". 2007

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Other information

Language

English

Type of outcome

Prezentace na konferencích

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords in English

cannabinoid receptor type 1; behavioural sensitization; immunofluorescence

Tags

behavioural sensitization, cannabinoid receptor type 1, immunofluorescence

Tags

International impact

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Abstract

V originále

Image analysis disclosed the higher intensity of immunostaining for CB1 receptors in selected mesencephalic structures of the control animals than in methamphetamine treated rats. The down-regulation of CB1 receptors can decrease an inhibiting influence of GABA and thus the dopaminergic pathway activation by methamphetamine might be more intensive.

In Czech

Ve vybraných strukturách mesencephala bylo pomocí imunofluorescence detekováno větší množství kanabinoidních CB1 receptorů u kontrolních laboratorních potkanů než u potkanů po opakovaném podávání metamphetaminu. Změna v expresi CB1 receptorů může snižovat inhibiční vliv GABA, a tím zvýšit aktivaci dopaminergního okruhu metamphetaminem.

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Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.