Differences in the effect of second-generation antipsychotics
on prolactinaemia: Six weeks open-label trial in female
in-patients

J 2007

Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients

ŠVESTKA, Jaromír, Oldřich SYNEK and Jana TOMANOVÁ

Basic information

Original name

Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients

Name in Czech

Rozdílnost efektu antipsychotik druhé generace na prolaktinémii. Šestitýdenní otevřená studie u pacientů ženského pohlaví

Name (in English)

Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients

Authors

ŠVESTKA, Jaromír, Oldřich SYNEK and Jana TOMANOVÁ

Edition

Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2007, 0172-780X

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.443

Organization unit

Faculty of Medicine

UT WoS

000252066300027

Keywords in English

second-generation antipsychotics; hyperprolactinaemia; prevalence; dynamics of change; correlations with other parameters

Abstract

ORIG EN

V originále

The main objective was to evaluate the effect of five second-generation antipsychotics (amisulpride, quetiapine, olanzapine, risperidone, and zotepine) on prolactinaemia during 6 week therapy in 433 female in-patients with mainly schizophrenic disorders. Secondary objectives included identification of dynamics of change in serum prolactin levels and correlations of changes of prolactinaemia with some demographic and clinical parameters. The trial was a prospective, open-label, single-center one with a flexible dosing of SGAs. The therapeutic effect of SGAs was assessed by a change of scores of CGI-S and CGI-I scales from a baseline to the endpoint. Blood samples were taken in the morning under fasting condition.

In English

The main objective was to evaluate the effect of five second-generation antipsychotics (amisulpride, quetiapine, olanzapine, risperidone, and zotepine) on prolactinaemia during 6 week therapy in 433 female in-patients with mainly schizophrenic disorders. Secondary objectives included identification of dynamics of change in serum prolactin levels and correlations of changes of prolactinaemia with some demographic and clinical parameters. The trial was a prospective, open-label, single-center one with a flexible dosing of SGAs. The therapeutic effect of SGAs was assessed by a change of scores of CGI-S and CGI-I scales from a baseline to the endpoint. Blood samples were taken in the morning under fasting condition.

Detailed Information on Publication Record