ŠVESTKA, Jaromír, Oldřich SYNEK and Jana TOMANOVÁ. Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2007, vol. 28, No 6, p. 881-888. ISSN 0172-780X.
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Basic information
Original name Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients
Name in Czech Rozdílnost efektu antipsychotik druhé generace na prolaktinémii. Šestitýdenní otevřená studie u pacientů ženského pohlaví
Name (in English) Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients
Authors ŠVESTKA, Jaromír, Oldřich SYNEK and Jana TOMANOVÁ.
Edition Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2007, 0172-780X.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.443
Organization unit Faculty of Medicine
UT WoS 000252066300027
Keywords in English second-generation antipsychotics; hyperprolactinaemia; prevalence; dynamics of change; correlations with other parameters
Tags correlations with other parameters, dynamics of change, hyperprolactinaemia, prevalence, second-generation antipsychotics
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Eva Češková, CSc., učo 726. Changed: 30/6/2009 09:54.
Abstract
The main objective was to evaluate the effect of five second-generation antipsychotics (amisulpride, quetiapine, olanzapine, risperidone, and zotepine) on prolactinaemia during 6 week therapy in 433 female in-patients with mainly schizophrenic disorders. Secondary objectives included identification of dynamics of change in serum prolactin levels and correlations of changes of prolactinaemia with some demographic and clinical parameters. The trial was a prospective, open-label, single-center one with a flexible dosing of SGAs. The therapeutic effect of SGAs was assessed by a change of scores of CGI-S and CGI-I scales from a baseline to the endpoint. Blood samples were taken in the morning under fasting condition.
Abstract (in English)
The main objective was to evaluate the effect of five second-generation antipsychotics (amisulpride, quetiapine, olanzapine, risperidone, and zotepine) on prolactinaemia during 6 week therapy in 433 female in-patients with mainly schizophrenic disorders. Secondary objectives included identification of dynamics of change in serum prolactin levels and correlations of changes of prolactinaemia with some demographic and clinical parameters. The trial was a prospective, open-label, single-center one with a flexible dosing of SGAs. The therapeutic effect of SGAs was assessed by a change of scores of CGI-S and CGI-I scales from a baseline to the endpoint. Blood samples were taken in the morning under fasting condition.
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