Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study.

BAREŠ, Martin, Petr KAŇOVSKÝ and Ivan REKTOR. Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study. Parkinsonism and Related Disorders. Oxford: Elsevier, 2007, vol. 13, No 8, p. 489-494. ISSN 1353-8020.

Basic information

Original name

Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study.

Name in Czech

Porušená intrakortikální excitabilita v časné fázi Parkinsonovy nemoci je vázána na dávku L-DOPA: Prospektivní, 12 měsíční studie s párovou TMS

Authors

BAREŠ, Martin (203 Czech Republic, guarantor), Petr KAŇOVSKÝ (203 Czech Republic) and Ivan REKTOR (203 Czech Republic)

Edition

Parkinsonism and Related Disorders, Oxford, Elsevier, 2007, 1353-8020

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.021

RIV identification code

RIV/00216224:14110/07:00023161

Organization unit

Faculty of Medicine

UT WoS

000251753500005

Keywords in English

Parkinson disease- paired TMS- L-DOPA- intracortical excitability

Tags

International impact, Reviewed

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Abstract

V originále

We were interested to know if chronic l-DOPA treatment in Parkinson's disease (PD) patients could restore impairment of the intracortical excitability, when this difference could occur, and if it was related to the total daily dose of l-DOPA. Twelve patients with early PD were studied using paired transcranial magnetic stimulation before the administration of l-DOPA, and then after 3, 6, and 12 months of l-DOPA treatment. The level of disturbed intracortical excitability strongly correlated with the total daily dose of l-DOPA. The level of cortical excitability in PD patients seems to be indirectly related to the nigro-striatal functioning.

In Czech

Porušená intrakortikální excitabilita v časné fázi Parkinsonovy nemoci je vázána na dávku L-DOPA: Prospektivní, 12 měsíční studie s párovou TMS

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Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.