BAREŠ, Martin, Petr KAŇOVSKÝ and Ivan REKTOR. Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study. Parkinsonism and Related Disorders. Oxford: Elsevier, 2007, vol. 13, No 8, p. 489-494. ISSN 1353-8020.
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Basic information
Original name Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study.
Name in Czech Porušená intrakortikální excitabilita v časné fázi Parkinsonovy nemoci je vázána na dávku L-DOPA: Prospektivní, 12 měsíční studie s párovou TMS
Authors BAREŠ, Martin (203 Czech Republic, guarantor), Petr KAŇOVSKÝ (203 Czech Republic) and Ivan REKTOR (203 Czech Republic).
Edition Parkinsonism and Related Disorders, Oxford, Elsevier, 2007, 1353-8020.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.021
RIV identification code RIV/00216224:14110/07:00023161
Organization unit Faculty of Medicine
UT WoS 000251753500005
Keywords in English Parkinson disease- paired TMS- L-DOPA- intracortical excitability
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Ivan Rektor, CSc., učo 1073. Changed: 18/6/2009 09:17.
Abstract
We were interested to know if chronic l-DOPA treatment in Parkinson's disease (PD) patients could restore impairment of the intracortical excitability, when this difference could occur, and if it was related to the total daily dose of l-DOPA. Twelve patients with early PD were studied using paired transcranial magnetic stimulation before the administration of l-DOPA, and then after 3, 6, and 12 months of l-DOPA treatment. The level of disturbed intracortical excitability strongly correlated with the total daily dose of l-DOPA. The level of cortical excitability in PD patients seems to be indirectly related to the nigro-striatal functioning.
Abstract (in Czech)
Porušená intrakortikální excitabilita v časné fázi Parkinsonovy nemoci je vázána na dávku L-DOPA: Prospektivní, 12 měsíční studie s párovou TMS
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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