| DOUBEK, Michael, Jan MUŽÍK, Tomáš SZOTKOWSKI, Vladimír KOZA, Petr CETKOVSKÝ, Tomáš KOZÁK, Pavel ŽÁK, Jaroslava VOGLOVÁ, Soňa ŠTRUNCOVÁ, Ladislav DUŠEK a Karel INDRÁK. Is FLT3 internal tandem duplication significant indicator for allogeneic transplantation in acute myeloid leukemia? An analysis of patients from the Czech Acute Leukemia Clinical Register (ALERT). Neoplasma. Bratislava, 2007, roč. 54, č. 1, s. 89-94. ISSN 0028-2685. |
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@article{747149,
author = {Doubek, Michael and Mužík, Jan and Szotkowski, Tomáš and Koza, Vladimír and Cetkovský, Petr and Kozák, Tomáš and Žák, Pavel and Voglová, Jaroslava and Štruncová, Soňa and Dušek, Ladislav and Indrák, Karel},
article_location = {Bratislava},
article_number = {1},
keywords = {HUMAN HEMATOLOGIC MALIGNANCIES; ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; FLT3-ACTIVATING MUTATIONS; PROGNOSTIC-SIGNIFICANCE; RISK GROUP; 12 TRIALS; AML 10; CYTOGENETICS; EXPRESSION},
language = {cze},
issn = {0028-2685},
journal = {Neoplasma},
title = {Is FLT3 internal tandem duplication significant indicator for allogeneic transplantation in acute myeloid leukemia? An analysis of patients from the Czech Acute Leukemia Clinical Register (ALERT)},
volume = {54},
year = {2007}
}
TY - JOUR
ID - 747149
AU - Doubek, Michael - Mužík, Jan - Szotkowski, Tomáš - Koza, Vladimír - Cetkovský, Petr - Kozák, Tomáš - Žák, Pavel - Voglová, Jaroslava - Štruncová, Soňa - Dušek, Ladislav - Indrák, Karel
PY - 2007
TI - Is FLT3 internal tandem duplication significant indicator for allogeneic transplantation in acute myeloid leukemia? An analysis of patients from the Czech Acute Leukemia Clinical Register (ALERT)
JF - Neoplasma
VL - 54
IS - 1
SP - 89-94
EP - 89-94
SN - 00282685
KW - HUMAN HEMATOLOGIC MALIGNANCIES
KW - ACUTE PROMYELOCYTIC LEUKEMIA
KW - ACUTE MYELOGENOUS LEUKEMIA
KW - FLT3-ACTIVATING MUTATIONS
KW - PROGNOSTIC-SIGNIFICANCE
KW - RISK GROUP
KW - 12 TRIALS
KW - AML 10
KW - CYTOGENETICS
KW - EXPRESSION
N2 - AML patients, we performed an analysis of all patients with FLT3 mutations registered in the Czech Acute Leukemia Clinical Register (ALERT) from 2003 till the end of 2005. Within the mentioned period 170 patients with AML of median age 56 years (23-77) were investigated for FLT3 mutation, within them 36 cases (21 %) with FLT3 mutations (32 FLT3 ITD and 4 FLT3 D835) were found.Out of FLT3 ITD positive patients 13 had allogeneic transplantation, 20 patients with mutations of FLT3 were treated with chemotherapy without transplantation. Results of the treatment of these patients were compared with the results of the group of patients without FLT3 mutation, which was according to other characteristics identical with the group of patients with FLT3 mutations (n=134). Median overall survival (OS) was significantly shorter for patients with FLT3 ITD (34.8 weeks) than for those without FLT3 mutations (67.7 weeks; P=0.028). Median OS of patients with FLT3 ITD who had allogeneic transplantation was 42.5 weeks; median OS of patients with FLT3 ITD treated only with chemotherapy was 29.6 weeks (P=0.362). After allogeneic transplantation, median OS of FLT3 mutations negative patients was similar to FLT3 ITD positive patients (46.7 versus 42.5 weeks; P=0.443). Our results suggest that at present there is no strong evidence that FLT3 status alone should influence the decision to proceed to allogeneic transplantation in AML patients.
ER -
DOUBEK, Michael, Jan MUŽÍK, Tomáš SZOTKOWSKI, Vladimír KOZA, Petr CETKOVSKÝ, Tomáš KOZÁK, Pavel ŽÁK, Jaroslava VOGLOVÁ, Soňa ŠTRUNCOVÁ, Ladislav DUŠEK a Karel INDRÁK. Is FLT3 internal tandem duplication significant indicator for allogeneic transplantation in acute myeloid leukemia? An analysis of patients from the Czech Acute Leukemia Clinical Register (ALERT). \textit{Neoplasma}. Bratislava, 2007, roč.~54, č.~1, s.~89-94. ISSN~0028-2685.
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