Baroreflex Sensitivity And A1166C Polymorphism In AT1 Receptor Gene

JÍRA, Miroslav, Eva ZÁVODNÁ, Nataša HONZÍKOVÁ, Zuzana NOVÁKOVÁ, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ and Bohumil FIŠER. Baroreflex Sensitivity And A1166C Polymorphism In AT1 Receptor Gene. 2007.

Basic information

• Original name: Baroreflex Sensitivity And A1166C Polymorphism In AT1 Receptor Gene
• Name in Czech: Citlivost baroreflexu a polymorfismus A1166C v genu pro AT1 receptor
• Authors: JÍRA, Miroslav (203 Czech Republic), Eva ZÁVODNÁ (203 Czech Republic), Nataša HONZÍKOVÁ (203 Czech Republic, guarantor), Zuzana NOVÁKOVÁ (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Bohumil FIŠER (203 Czech Republic).
• Edition: 2007.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30201 Cardiac and Cardiovascular systems
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/07:00023323
• Organization unit: Faculty of Medicine
• Keywords (in Czech): citlivost baroreflexu; receptor1 pro angiotenzin 2; polymorfismus; spektrální analýza
• Keywords in English: baroreflex sensitivity; angiotenzin II type 1 receptor; polymorphism; spectral analysis
• Tags: baroreflex sensitivity, polymorphism, spectral analysis
• Tags: International impact, Reviewed

Abstract

Decreased baroreflex sensitivity (BRS in ms/mmHg; BRSf in mHz/mmHg) contributes to the development of hypertension and to the risk of sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate association of single nucleotide polymorphism A1166C in angiotensin II type 1 receptor (AT1R) gene with BRS and BRSf in man. We found significant association of A1166C polymorphism in AT1 receptor gene with baroreflex sensitivity. Less frequent allele was associated with decreased BRS and BRSf.

Abstract (in Czech)

Snížená citlivost baroreflexu (BRS v ms/mmHg, BRSf v mHz/mmHg) přispívá ke vzniku hypertenze a náhlé srdeční smrti po infarktu myokardu. Cílem této studie bylo vyhodnotit asociaci polymorfismu A1166C v genu pro AT1 receptor s BRS a BRSf u člověka. Byla nalezena signifikantní asociace polymorfismu A1166C v genu pro AT1 receptor s citlivostí baroreflexu. Přítomnost méně četné alely byla asociována se sníženou BRS a BRSf.

Links

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases