Baroreflex Sensitivity And A1166C Polymorphism In AT1 Receptor Gene

JÍRA, Miroslav, Eva ZÁVODNÁ, Nataša HONZÍKOVÁ, Zuzana NOVÁKOVÁ, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ and Bohumil FIŠER. Baroreflex Sensitivity And A1166C Polymorphism In AT1 Receptor Gene. 2007.

Basic information

Original name

Baroreflex Sensitivity And A1166C Polymorphism In AT1 Receptor Gene

Name in Czech

Citlivost baroreflexu a polymorfismus A1166C v genu pro AT1 receptor

Authors

JÍRA, Miroslav (203 Czech Republic), Eva ZÁVODNÁ (203 Czech Republic), Nataša HONZÍKOVÁ (203 Czech Republic, guarantor), Zuzana NOVÁKOVÁ (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Bohumil FIŠER (203 Czech Republic)

Edition

2007

---

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/07:00023323

Organization unit

Faculty of Medicine

Keywords (in Czech)

citlivost baroreflexu; receptor1 pro angiotenzin 2; polymorfismus; spektrální analýza

Keywords in English

baroreflex sensitivity; angiotenzin II type 1 receptor; polymorphism; spectral analysis

Tags

baroreflex sensitivity, polymorphism, spectral analysis

Tags

International impact, Reviewed

---

Abstract

V originále

Decreased baroreflex sensitivity (BRS in ms/mmHg; BRSf in mHz/mmHg) contributes to the development of hypertension and to the risk of sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate association of single nucleotide polymorphism A1166C in angiotensin II type 1 receptor (AT1R) gene with BRS and BRSf in man. We found significant association of A1166C polymorphism in AT1 receptor gene with baroreflex sensitivity. Less frequent allele was associated with decreased BRS and BRSf.

In Czech

Snížená citlivost baroreflexu (BRS v ms/mmHg, BRSf v mHz/mmHg) přispívá ke vzniku hypertenze a náhlé srdeční smrti po infarktu myokardu. Cílem této studie bylo vyhodnotit asociaci polymorfismu A1166C v genu pro AT1 receptor s BRS a BRSf u člověka. Byla nalezena signifikantní asociace polymorfismu A1166C v genu pro AT1 receptor s citlivostí baroreflexu. Přítomnost méně četné alely byla asociována se sníženou BRS a BRSf.

---

Links

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases