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@article{748680,
author = {Litzman, Jiří and Vlková, Marcela and Pikulová, Zdenka and Štikarovská, Dagmar and Lokaj, Jindřich},
article_number = {2},
keywords = {common variable immunodefciency; IgA deficiency; lymphocyte subpopulations},
language = {eng},
issn = {0009-9104},
journal = {Clin Exp Immunol},
title = {T and B lymphocyte subpopulations and activation/differentiation markers in patients with selective IgA deficiency},
volume = {147},
year = {2007}
}
TY - JOUR
ID - 748680
AU - Litzman, Jiří - Vlková, Marcela - Pikulová, Zdenka - Štikarovská, Dagmar - Lokaj, Jindřich
PY - 2007
TI - T and B lymphocyte subpopulations and activation/differentiation markers in patients with selective IgA deficiency
JF - Clin Exp Immunol
VL - 147
IS - 2
SP - 249-254
EP - 249-254
SN - 00099104
KW - common variable immunodefciency
KW - IgA deficiency
KW - lymphocyte subpopulations
N2 - Selective deficiency of immunoglobulin A (IgAD) and common variable immunodeficiency (CVID) are genetically closely related diseases, both of unknown pathogenesis. A plethora of abnormalities in lymphocyte subpopulations and expression of activation markers were repeatedly documented in CVID patients, while almost no data are available about lymphocyte subpopulations in IgAD patients. We determined basic lymphocyte subpopulations and those subpopulations that were reported to be abnormal in CVID patients (CD25, human leucocyte antigen (HLA)-DR CD45RA, CD45RO, CD27, CD28 and CD29 on both CD4(+) and CD8(+) cells, CD57 and CD38 on CD8(+) cells, CD21, CD27, IgM, IgD on B lymphocytes) in 85 patients with IgAD, 47 patients with CVID and in 65 healthy controls. Statistical analysis was performed by the Mann-Whitney U-test; significant P-values were determined by means of Bonferoni's correction. Our results showed an increase in the relative number of CD8(+) cells and a decrease in the absolute number of CD4(+) cells compared to healthy people, but similar abnormalities in CVID patients were much more expressed. IgAD patients had significantly decreased expression of HLA-DR and increased expression of CD25 on CD4(+) lymphocytes, also CD29 expression was decreased on CD8(+) cells, while other activation/differentiation markers on T cells (including the expression of CD45RA and CD45RO antigens) were not changed. There were no statistically significant abnormalities in B lymphocyte developmental stages in IgAD patients compared to healthy controls. Our observation showed that the majority of T and B lymphocyte subpopulation abnormalities described previously in CVID are not present in IgAD patients.
ER -
LITZMAN, Jiří, Marcela VLKOVÁ, Zdenka PIKULOVÁ, Dagmar ŠTIKAROVSKÁ and Jindřich LOKAJ. T and B lymphocyte subpopulations and activation/differentiation markers in patients with selective IgA deficiency. \textit{Clin Exp Immunol}. vol.~147, No~2, p.~249-254. ISSN~0009-9104. 2007.
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