KUČEROVÁ, Jana, Leoš LANDA, Karel ŠLAIS and Alexandra ŠULCOVÁ. Are there gender or seasonal variabilities in mouse behavioral response to acute and chronic ecstasy? European Neuropsychopharmacology. Amsterdam (The Netherlands): Elsevier, 2007, vol. 17, Suppl. 4, p. 552-552. ISSN 0924-977X.
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Basic information
Original name Are there gender or seasonal variabilities in mouse behavioral response to acute and chronic ecstasy?
Name in Czech Ovlivňuje pohlaví nebo sezónní vlivy behaviorální odpověď myší na akutní a chronické podávání extáze?
Authors KUČEROVÁ, Jana, Leoš LANDA, Karel ŠLAIS and Alexandra ŠULCOVÁ.
Edition European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2007, 0924-977X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Austria
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.430
Organization unit Faculty of Medicine
UT WoS 000251231901264
Keywords in English gender differences; behavioural sensitization; mice; ecstasy; season
Tags behavioural sensitization, ecstasy, gender differences, mice, season
Tags International impact
Changed by Changed by: doc. PharmDr. Jana Rudá, Ph.D., učo 169493. Changed: 29/6/2009 11:45.
Abstract
In this study we summarized and statistically processed results of four experiments of the same design proceeded during aproximately one year to evaluate gender differences on larger groups of mice treated with MDMA, and the females included were intact animals, but also ovariectomized females without or with estrogen substitution in the last experiment. A possibility of seasonal impact on behavioral variabilities was also evaluated.
Abstract (in Czech)
Studie navazuje na experimenty, které prokázaly vyšší vulnerabilitu myších samic k rozvoji behaviorální sensitizace během opakovaného intermitentního podávání MDMA. Naopak samci reagovali signifikantně více než samice na akutní podání MDMA. Význam těchto pohlavních rozdílů je ještě zřejmější, když je vzat v úvahu fenomén habituace (snížení lokomoce při opakování testu otevřeného pole, který byl použit).
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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