ŠLAIS, Karel, Ivan VOŘÍŠEK, Norbert ZOREMBA, Aleš HOMOLA, Lesia DMYTRENKO and Eva SYKOVÁ. Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus. Experimental Neurology. United States: Academic Press, 2008, vol. 209, No 1, p. 145-154. ISSN 0014-4886.
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Basic information
Original name Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus
Name in Czech Difúze a metabolizmus v mozkové kůře potkana v průběhu pilokarpinem indukovaného epileptickáho záchvatu
Authors ŠLAIS, Karel (203 Czech Republic, guarantor), Ivan VOŘÍŠEK (203 Czech Republic), Norbert ZOREMBA (276 Germany), Aleš HOMOLA (203 Czech Republic), Lesia DMYTRENKO (804 Ukraine) and Eva SYKOVÁ (203 Czech Republic).
Edition Experimental Neurology, United States, Academic Press, 2008, 0014-4886.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.974
RIV identification code RIV/00216224:14110/08:00025693
Organization unit Faculty of Medicine
UT WoS 000252500900020
Keywords in English Diffusion; ADCW; Microdialysis; Pilocarpine; Epilepsy; Glucose; Glutamate; Pyruvate; Lactate; Potassium
Tags ADCW, Diffusion, epilepsy, glucose, glutamate, lactate, Microdialysis, pilocarpine, potassium, Pyruvate
Tags International impact, Reviewed
Changed by Changed by: MUDr. Mgr. Karel Šlais, Ph.D., učo 19989. Changed: 23/6/2009 09:21.
Abstract
The real-time iontophoretic method using tetramethylammonium-selective microelectrodes and diffusion-weighted magnetic resonance imaging were used to measure the extracellular space volume fraction, tortuosity and apparent diffusion coefficient of water (ADCW) 240 min after the administration of pilocarpine in urethane-anaesthetized rats. The obtained data were correlated with extracellular lactate, glucose, and glutamate concentrations and the lactate/pyruvate-ratio, determined by intracerebral microdialysis.
Abstract (in Czech)
Práce studovala změny difúzních parametrů v kortexu mozku potkana při epileptickém záchvatu navozeném pilokarpinem. Dále byly sledovány extracelulární koncentrace laktátu, glutamátu, glukózy a pyruvátu a jejich závislost na změnách velikosti extracelulárního prostoru.
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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