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@article{748991,
author = {Pistovčáková, Jana and Dostálek, Miroslav and Šulcová, Alexandra and Ježová, Daniela},
article_location = {Stuttgart-New York},
article_number = {40},
keywords = {tiagabine; olfactory bulbectomy; rat; immunity; behaviour; endocrine},
language = {eng},
issn = {0176-3679},
journal = {Pharmacopsychiatry},
note = {preliminary on-line publication},
title = {Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression},
volume = {2007},
year = {2007}
}
TY - JOUR
ID - 748991
AU - Pistovčáková, Jana - Dostálek, Miroslav - Šulcová, Alexandra - Ježová, Daniela
PY - 2007
TI - Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression
JF - Pharmacopsychiatry
VL - 2007
IS - 40
SP - 1-6
EP - 1-6
PB - Georg Thieme Verlag KG
SN - 01763679
N1 - preliminary on-line publication
KW - tiagabine
KW - olfactory bulbectomy
KW - rat
KW - immunity
KW - behaviour
KW - endocrine
N2 - The purpose of the study was to test a potential antidepressant effect of the 3rd generation antiepileptic tiagabine in rats chronically stressed by anosmia due to bilateral olfactory bulbectomy (OB), which is a well-established animal model of human depression resembling behavioural, immune and endocrine changes (Leonard and Tuite, 1981). OB rats show significant increase in locomotor/exploratory activities in the open-field test, and altered plasma stress hormone levels and suppressed phagocytosis of leukocytes what we have examined in the present experiments. After repeated tiagabine (12 mg/kg/day, IP) administration we measured the locomotor activity in the open-field test, adrenalin, noradrenaline, dopamine and corticosterone plasma levels and the leukocyte phagocytic function. Also the differential white blood cell counts were measured. Repeated tiagabine treatment elicited a significant decrease of the locomotor hyperactivity in the open field test. Taking into account that clinically approved antidepressants reverse OB related behavioural and immune disorders (Leonard and Tuite, 1981) the results indicate the hypothesized antidepressant activity of tiagabine. The OB-induced changes in leukocyte differential counts were not found in the tiagabine-treated group. The OB-induced reduction in plasma noradrenaline levels was normalised following tiagabine treatment.
ER -
PISTOVČÁKOVÁ, Jana, Miroslav DOSTÁLEK, Alexandra ŠULCOVÁ and Daniela JEŽOVÁ. Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. \textit{Pharmacopsychiatry}. Stuttgart-New York: Georg Thieme Verlag KG, 2007, vol.~2007, No~40, p.~1-6. ISSN~0176-3679.
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