REKTOROVÁ, Irena, Jane BARRETT, Michal MIKL, Ivan REKTOR and Tomáš PAUS. Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease. Movement Disorders. Philadelphia: Lippincott Williams and Wilkins, vol. 22, No 14, p. 2043-2051, 8 pp. ISSN 0885-3185. 2007.
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Basic information
Original name Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease.
Name in Czech Funkční abnormality v primárním orofaciálním senzomotirckém kortextu u Parkinsonovy nemoci při čtení
Authors REKTOROVÁ, Irena (203 Czech Republic, guarantor), Jane BARRETT (124 Canada), Michal MIKL (203 Czech Republic), Ivan REKTOR (203 Czech Republic) and Tomáš PAUS (826 United Kingdom of Great Britain and Northern Ireland).
Edition Movement Disorders, Philadelphia, Lippincott Williams and Wilkins, 2007, 0885-3185.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.207
RIV identification code RIV/00216224:14110/07:00023382
Organization unit Faculty of Medicine
UT WoS 000250697300006
Keywords in English overt reading; paralinguistic aspects of speech; Parkinson's disease; functional magnetic resonance imaging
Tags Functional magnetic resonance imaging, overt reading, paralinguistic aspects of speech, Parkinson's disease
Tags International impact, Reviewed
Changed by Changed by: Ing. Michal Mikl, Ph.D., učo 133966. Changed: 18/6/2009 08:57.
Abstract
Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the BOLD response to overt sentence reading in: 9 treated female patients with mild to moderate PD and 8 age-matched healthy female controls. Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects of speech production. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primary orofacial sensorimotor cortex.
Abstract (in Czech)
Parkinsonova nemoc (PD) ovlivňuje řeč včetně respirace, fonace a artikulace. Měřili jsme BOLD odezvu během čtení u devíti pacientů s nízkým a středním stupněm PD a u osmi zdravých kontrol (vše ženy). Při čtení jsme nahrávali řeč, abycho mohli ohodnotit, které oblasti mozku souvisejí s variacemi v iniciaci a paralingvistických aspektech tvorby řeči. U PD pacientů ve srovnání se zdravými kontrolami jsme nalezli významně vyšší BOLD signál v pravém primárním orofaciálním senzomotorickém kortexu a robustnější korelaci mezi sledovanými řečovými parametry a změnou BOLD signálu a to zejména v levém primárním orofaciálním sensomotorickém kortexu.
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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