Other formats:
BibTeX
LaTeX
RIS
@article{749767, author = {Slabý, Ondřej and Svoboda, Marek and Fabian, Pavel and Šmerdová, Tamara and Knoflíčková, Dana and Bednaříková, Markéta and Nenutil, Rudolf and Vyzula, Rostislav}, article_location = {Basel}, article_number = {5-6}, keywords = {microRNA; colorectal cancer; pathogenesis}, language = {cze}, issn = {0030-2414}, journal = {Oncology}, title = {Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer}, url = {http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=113489&Ausgabe=234514&ProduktNr=223857}, volume = {72}, year = {2008} }
TY - JOUR ID - 749767 AU - Slabý, Ondřej - Svoboda, Marek - Fabian, Pavel - Šmerdová, Tamara - Knoflíčková, Dana - Bednaříková, Markéta - Nenutil, Rudolf - Vyzula, Rostislav PY - 2008 TI - Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer JF - Oncology VL - 72 IS - 5-6 SP - 397-402 EP - 397-402 PB - S. Karger AG SN - 00302414 KW - microRNA KW - colorectal cancer KW - pathogenesis UR - http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=113489&Ausgabe=234514&ProduktNr=223857 N2 - Objectives: Development and metastases of colorectal cancer (CRC) are characterized by multiple genetic alterations. MicroRNAs (miRNAs) are endogenously expressed regulatory noncoding RNAs. Previous, mainly preclinical studies showed altered expression levels of several miRNAs in CRC. Methods: In our study, the expression levels of miR-21, miR-31, miR-143 and miR-145 in 29 primary colorectal carcinomas and 6 non-tumor adjacent tissue specimens were examined by real-time polymerase chain reaction. miRNA expression levels were also correlated with commonly used clinicopath-ologic features of CRC. Results: Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors. For the first time, a high expression of miR-21 was associated with lymph node positivity (p = 0.025) and the development of distant metastases (p = 0.009) in CRC patients. Thus, expression of miR-21 correlated with CRC clinical stage (p = 0.032). Furthermore, tumors >50 mm in maximal tumor diameter were characterized by lower expression of miR-143 (p = 0.006) and miR-145 (p = 0.003). We found no correlation between analyzed miRNAs and serum levels of carcinoembryonic antigen. Conclusion: Our results suggest possible roles of miR-21, miR-31, miR-143 and miR-145 in CRC. ER -
SLABÝ, Ondřej, Marek SVOBODA, Pavel FABIAN, Tamara ŠMERDOVÁ, Dana KNOFLÍČKOVÁ, Markéta BEDNAŘÍKOVÁ, Rudolf NENUTIL and Rostislav VYZULA. Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer. \textit{Oncology}. Basel: S. Karger AG, 2008, vol.~72, 5-6, p.~397-402. ISSN~0030-2414.
|