BERÁNEK, Michal, Petr KOLÁŘ, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ and Anna VAŠKŮ. Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy. Diabetes Res Clin Pract. Elsevier, 2007, vol. 79, No 2, p. 362-367. ISSN 0168-8227.
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Basic information
Original name Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy
Name in Czech Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy
Authors BERÁNEK, Michal (203 Czech Republic, belonging to the institution), Petr KOLÁŘ (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic, belonging to the institution), Kateřina KAŇKOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition Diabetes Res Clin Pract, Elsevier, 2007, 0168-8227.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30202 Endocrinology and metabolism
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.823
RIV identification code RIV/00216224:14110/07:00020817
Organization unit Faculty of Medicine
UT WoS 000253370200028
Keywords in English basic fibroblast growth factor; proliferative diabetic retinopathy; haplotype; polymorphisms
Tags basic fibroblast growth factor, haplotype, polymorphisms, proliferative diabetic retinopathy
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Petr Kolář, Ph.D., učo 63563. Changed: 29/10/2012 10:21.
Abstract
The basic fibroblast growth factor (bFGF) is considered to be one of the candidate genes in the processes of tumour growth and angiogenesis. The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. Allele, genotype and haplotype frequencies were determined in the association study comprising three groups of Caucasian subjects (n = 488) (diabetics with/PDR/and without retinopathy/non-PDR/and non-diabetics/ non-DM/) in order to identify genetic marker for PDR. The plasma level of the bFGF protein was analysed by ELISA method. Significantly higher frequencies of 754C allele of the new 754C/G polymorphisms was found between PDR and non-DM group (p=0.05, OR=1.38). The comparison of plasma level of the bFGF showed statistically significant difference among studied groups (p=0.001). The bFGF plasma level in PDR group was significantly higher than in the groups of non-PDR and non-DM (p=0.017, p=0.001, respectively) and was significantly higher for CC and GC genotypes of 754C/G polymorphism in PDR group (p=0.006). Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of PDR. However, the regulatory mechanisms of the bFGF level need further examinations.
Abstract (in Czech)
The basic fibroblast growth factor (bFGF) is considered to be one of the candidate genes in the processes of tumour growth and angiogenesis. The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. Allele, genotype and haplotype frequencies were determined in the association study comprising three groups of Caucasian subjects (n = 488) (diabetics with/PDR/and without retinopathy/non-PDR/and non-diabetics/ non-DM/) in order to identify genetic marker for PDR. The plasma level of the bFGF protein was analysed by ELISA method. Significantly higher frequencies of 754C allele of the new 754C/G polymorphisms was found between PDR and non-DM group (p=0.05, OR=1.38). The comparison of plasma level of the bFGF showed statistically significant difference among studied groups (p=0.001). The bFGF plasma level in PDR group was significantly higher than in the groups of non-PDR and non-DM (p=0.017, p=0.001, respectively) and was significantly higher for CC and GC genotypes of 754C/G polymorphism in PDR group (p=0.006). Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of PDR. However, the regulatory mechanisms of the bFGF level need further examinations.
Links
GP303/05/P523, research and development projectName: Vztah genetických polymorfizmů v kandidátních genech účastnících se procesu angiogeneze k proliferativní retinopatii u diabetes mellitus 2. typu
Investor: Czech Science Foundation, Relationship between genetic variability in candidate genes involved in angiogenesis and proliferative retinopathy in Type 2 diabetes mellitu
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