PACHERNÍK, Jiří, Viktor HORVÁTH, Lukáš KUBALA, Petr DVOŘÁK, Alois KOZUBÍK and Aleš HAMPL. Neural Differentiation Potentiated by the Leukaemia Inhibitory Factor through Stat3 Signalling in Mouse Embryonal Carcinoma Cells. Folia Biologica. 2007, vol. 53, No 5, p. 157-163. ISSN 0015-5500. |
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@article{750451, author = {Pacherník, Jiří and Horváth, Viktor and Kubala, Lukáš and Dvořák, Petr and Kozubík, Alois and Hampl, Aleš}, article_number = {5}, keywords = {neural differentiation; leukaemia inhibitory factor; STAT3; embryonal carcinoma cells P19}, language = {eng}, issn = {0015-5500}, journal = {Folia Biologica}, title = {Neural Differentiation Potentiated by the Leukaemia Inhibitory Factor through Stat3 Signalling in Mouse Embryonal Carcinoma Cells}, volume = {53}, year = {2007} }
TY - JOUR ID - 750451 AU - Pacherník, Jiří - Horváth, Viktor - Kubala, Lukáš - Dvořák, Petr - Kozubík, Alois - Hampl, Aleš PY - 2007 TI - Neural Differentiation Potentiated by the Leukaemia Inhibitory Factor through Stat3 Signalling in Mouse Embryonal Carcinoma Cells JF - Folia Biologica VL - 53 IS - 5 SP - 157-163 EP - 157-163 SN - 00155500 KW - neural differentiation KW - leukaemia inhibitory factor KW - STAT3 KW - embryonal carcinoma cells P19 N2 - LIF is a cytokine playing a key role in the regulation of self-renewal and maintenance of undifferentiated state in mouse ES cells. The response of pluripotent cells to LIF is mediated mainly by the STAT3 and ERK signalling pathways. Recently, we have shown that LIF potentiated retinoic acid-induced neural differentiation of pluripotent mouse embryonal carcinoma P19 cells. Here we demonstrate that pro-neural effects of LIF and partially also of retinoic acid are abolished by inhibition of the JAK2->STAT3 signalling pathway. In contrast, inhibition of the MEK1->ERK signalling pathway does not exhibit any effect. These results suggest that in neurogenic regions, cooperative action of LIF and other neuro-differentiation-inducing factors, such as retinoic acid, may be mediated by the STAT3 signalling pathway. ER -
PACHERNÍK, Jiří, Viktor HORVÁTH, Lukáš KUBALA, Petr DVOŘÁK, Alois KOZUBÍK and Aleš HAMPL. Neural Differentiation Potentiated by the Leukaemia Inhibitory Factor through Stat3 Signalling in Mouse Embryonal Carcinoma Cells. \textit{Folia Biologica}. 2007, vol.~53, No~5, p.~157-163. ISSN~0015-5500.
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