Detailed Information on Publication Record
2007
Polymorphism at position-308 of the TNF-alpha gene influences outcome of anti-TNF-alpha therapy in rheumatoid arthritis:preliminary results
NĚMEC, Petr, Monika PÁVKOVÁ GOLDBERGOVÁ, Karel CHROUST, Anna VAŠKŮ, Miroslav SOUČEK et. al.Basic information
Original name
Polymorphism at position-308 of the TNF-alpha gene influences outcome of anti-TNF-alpha therapy in rheumatoid arthritis:preliminary results
Name in Czech
Polymorfismus v pozici -308 v genu pro TNF alfa ovlivňuje výsledek anti TNF alfa terapie u pacientů s revmatoidní artritidou: předběžné výsledky
Authors
NĚMEC, Petr (203 Czech Republic, guarantor), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic), Karel CHROUST (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic) and Miroslav SOUČEK (203 Czech Republic)
Edition
2007
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/07:00040010
Organization unit
Faculty of Medicine
Keywords in English
TNF; gene; rheumatoid; arthritis
Tags
Tags
International impact, Reviewed
Změněno: 6/4/2010 11:14, prof. RNDr. Monika Pávková Goldbergová, Ph.D.
V originále
Rheumatoid arthritis (RA) is a model of multigenic inflammatory disorder in which tumor necrosis factor-alpha (TNF-alpha) plays an important role. Genetic factors may be implicated in the susceptibility to disease initiation as well as in severity of disease course. Elevated levels of TNF-alpha in the plasma and synovial fluid from RA patients may be associated with polymorphisms in the promoter region of the TNF-alpha gene. The aim of this study was to elucidate putative association between the -308 G/A polymorphism in the promoter region of the TNF-alpha gene and susceptibility to onset and severity of RA. A total of 130 RA patients and a control group of 150 healthy subjects with similar age and sex distribution were available for the study. All patients fulfilled the American College of Rheumatology revised criteria for RA. RA patients had a disease duration of at least 2 years. Radiographs of both hands of all RA patients were scored with the Steinbrocker method. There were 15 patients of stage I (nonerosive form) of RA and 114 patients of stages II-IV (erosive form). To assess the RA patient's functional ability, the Health Assessment Questionnaire (HAQ) was used. The -308 G/A promoter polymorphism of the TNF-alpha gene was detected by polymerase chain reaction and restriction fragment length polymorphism analysis. No differences in genotype distribution and allelic frequences of -308 G/A TNF-alpha promoter polymorphism have been found between RA patients and the control group. Significant differences have been observed within the RA group divided according to the radiographic progression of disease based on the Steinbrocker radiographic score and functional ability (HAQ). These results suggest an association of the -308 G/A polymorphism of the TNF-alpha gene with the severity of RA.
In Czech
Polymorfismus v pozici -308 v genu pro TNF alfa ovlivňuje výsledek anti TNF alfa terapie u pacientů s revmatoidní artritidou: předběžné výsledky
Links
| NR7812, research and development project |
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