| VLČKOVÁ, Eva, Josef BEDNAŘÍK, Ladislav DUŠEK, Klaus TOYKA and Claudia SOMMER. Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Muscle & Nerve. San Francisco, California: J. Wiley, 2008, vol. 37, No 1, p. 50-60. ISSN 0148-639X. |
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@article{750878,
author = {Vlčková, Eva and Bednařík, Josef and Dušek, Ladislav and Toyka, Klaus and Sommer, Claudia},
article_location = {San Francisco, California},
article_number = {1},
keywords = {skin biopsy; epidermal nerve fiber density; painful neuropathy; quantitative sensory testing; skin biopsy; subepidermal nerve fiber density},
language = {eng},
issn = {0148-639X},
journal = {Muscle & Nerve},
title = {Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies},
volume = {37},
year = {2008}
}
TY - JOUR
ID - 750878
AU - Vlčková, Eva - Bednařík, Josef - Dušek, Ladislav - Toyka, Klaus - Sommer, Claudia
PY - 2008
TI - Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies
JF - Muscle & Nerve
VL - 37
IS - 1
SP - 50-60
EP - 50-60
PB - J. Wiley
SN - 0148639X
KW - skin biopsy
KW - epidermal nerve fiber density
KW - painful neuropathy
KW - quantitative sensory testing
KW - skin biopsy
KW - subepidermal nerve fiber density
N2 - In this prospective study, intraepidermal nerve fiber (IENFD) and subepidermal nerve plexus densities (SENPD) were quantified by immunostaining in skin punch biopsies from the distal calf in 99 patients with clinical symptoms of painful sensory neuropathy and from 37 age-matched healthy volunteers. The clinical diagnosis was based on history and abnormal thermal thresholds on quantitative sensory testing (QST). In patients with neuropathy, IENFD and SENPD were reduced to about 50% of controls. Elevated warm detection thresholds on QST correlated with IENFD but not with SENPD. Using receiver-operating characteristic curve (ROC) analysis of IENFD values, the diagnostic sensitivity for detecting neuropathy was 0.80 and the specificity 0.82. For SENPD, sensitivity was 0.81 and specificity 0.88. Analyzing both IENFD and SENPD together with ROC analysis, the diagnostic sensitivity was further improved to 0.92. The combined examination of IENFD and SENPD is a highly sensitive and specific diagnostic tool in patients suspected to suffer from painful sensory neuropathies with normal values in clinical neurophysiological studies.
ER -
VLČKOVÁ, Eva, Josef BEDNAŘÍK, Ladislav DUŠEK, Klaus TOYKA and Claudia SOMMER. Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. \textit{Muscle \&{} Nerve}. San Francisco, California: J. Wiley, 2008, vol.~37, No~1, p.~50-60. ISSN~0148-639X.
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