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@proceedings{751045, author = {Šimurda, Jiří and Šimurdová, Milena}, keywords = {T-tubules; quantitative model; calcium difusion; cardiac cell}, language = {eng}, title = {Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules}, year = {2007} }
TY - CONF ID - 751045 AU - Šimurda, Jiří - Šimurdová, Milena PY - 2007 TI - Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules KW - T-tubules KW - quantitative model KW - calcium difusion KW - cardiac cell N2 - Majority of L-type calcium channels in ventricular cardiomyocytes are located in transverse-axial tubular system (TATS) membrane, where they are inhomogenously distributed in clusters within dyads. The aim of numeric computations (software MATLAB, version 6) was to evaluate the effect of tubular Ca2+ buffering and of inhomogeneity in Ca channel distribution on [Ca2+]t distribution. We conclude that the observation of slower velocity of Ca2+ diffusion along TATS lumen related to expected velocity considering diffusion coefficient of bulk extracellular medium) can be explained at least partly by Ca binding within TATS. The inhomogeneities in Ca2+-channel distribution in TATS due to clustering within dyads has little effect on spatial and temporal changes in [Ca2+]t induced by excitations. ER -
ŠIMURDA, Jiří a Milena ŠIMURDOVÁ. \textit{Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules}. 2007.
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