LOKAJ, Jindřich, Vojtěch THON, Marcela VLKOVÁ, Tomáš FREIBERGER and Jiří LITZMAN. THE EXPRESSION OF THE Fc GAMMA RECEPTORS (CD16, CD32, CD64) ON LEUKOCYTES IN THE COMMON VARIABLE IMMUNODEFICIENCY (CVID). In 13th International Congress of Immunology. 2007.
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Basic information
Original name THE EXPRESSION OF THE Fc GAMMA RECEPTORS (CD16, CD32, CD64) ON LEUKOCYTES IN THE COMMON VARIABLE IMMUNODEFICIENCY (CVID)
Name in Czech Exprese Fcgama receptorů na leukocytech pacientů s běžným variabilním imunodeficitem(CVID)
Authors LOKAJ, Jindřich, Vojtěch THON, Marcela VLKOVÁ, Tomáš FREIBERGER and Jiří LITZMAN.
Edition 13th International Congress of Immunology, 2007.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 30102 Immunology
Country of publisher Brazil
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Medicine
Keywords in English common variable immunodeficiency, Ig Gamma receptors, immune activation
Tags International impact
Changed by Changed by: prof. MUDr. Jiří Litzman, CSc., učo 403. Changed: 27/1/2008 10:49.
Abstract
CVID is most frequent symptomatic primary hypogammaglobulinemia. The foundation of therapy for CVID is immunoglobulin replacement. The factors that influence the effect of this therapy are not elucidated. It should be supposed participation of receptors for immunoglobulins on professional phagocytes and lymphocytes. We have investigated 41 patients (13 males, 28 females, aged 10-77 years) and 44 age-related control persons. Quantitative expression of the Fc receptors on the surface of lymphocytes, monocytes, and granulocytes was determined by flow cytometry. Gene polymorphism of Fc receptors was determined by PCR. The expression of CD16, CD 32 and CD64 on lymphocytes and monocytes was comparable in patients and control persons, also the expression of CD16 and CD32 on granulocytes was similar in both groups. However, we have found marked differences in the expression of CD64 on granulocytes in CVID patients: in patients with high expression of CD64 on their granulocytes the clinical state and effectivity of standard treatment with intravenous immunoglobulin was significantly worse than in patients with low expression of this receptor. Our results suggest that the gravity in the clinical course of CVID patients and efficacy of immunoglobulin therapy may relate to the upregulation of Fc gamma receptor I (CD64) on granulocytes.
Abstract (in Czech)
Sledován výsky exprese Fc gama receptorů na povrchu leukocytů nemocných s běžným variabilním imunodeficitem.
Links
NR9035, research and development projectName: Specifická protilátková odpověď u pacientů s poruchami imunity
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