HOLOTŇÁKOVÁ, Tereza, Attila ZIEGELHOFFER, Anna OHRADANOVÁ, Alžbeta HULÍKOVÁ, Marie NOVÁKOVÁ, Juraj KOPÁČEK, Jaromír PASTOREK and Silvia PASTOREKOVÁ. Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes. Pflügers Archiv - European Journal Physiology. Ulm: Springer, 2007, vol. 456, No 2, p. 323-337. ISSN 0031-6768.
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Basic information
Original name Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes
Name in Czech Indukce karboanhydrázy IX hypoxií a chemickou disrupcí detekce kyslíku ve fibroblastech a kardiomyocytech potkana
Authors HOLOTŇÁKOVÁ, Tereza (703 Slovakia), Attila ZIEGELHOFFER (703 Slovakia), Anna OHRADANOVÁ (703 Slovakia), Alžbeta HULÍKOVÁ (703 Slovakia), Marie NOVÁKOVÁ (203 Czech Republic, guarantor), Juraj KOPÁČEK (703 Slovakia), Jaromír PASTOREK (703 Slovakia) and Silvia PASTOREKOVÁ (703 Slovakia).
Edition Pflügers Archiv - European Journal Physiology, Ulm, Springer, 2007, 0031-6768.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.842
RIV identification code RIV/00216224:14110/07:00033011
Organization unit Faculty of Medicine
UT WoS 000254906300007
Keywords in English Carbonic anhydrase IX;hypoxia;oxygen sensing;tumor;cardiomyocytes;TCA cycle;succinate
Tags Carbonic anhydrase IX, cardiomyocytes, hypoxia, oxygen sensing, succinate, TCA cycle, Tumor
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Marie Nováková, Ph.D., učo 1188. Changed: 2/4/2010 10:43.
Abstract
CA IX is an active transmembrane carbonic anhydrase isoform functionally implicated in cell adhesion and pH control. Human CA IX is strongly induced by hypoxia and frequently associated with various tumors. In this study, we investigated the expression of the rat CA IX in response to chronic hypoxia and to treatment with chemical compounds that disrupt oxygen sensing, including dimethyloxalylglycine, dimethylester succinate, diazoxide, and tempol. We brought the evidence that expression of CA IX is regulated by hypoxia and hypoxia-mimicking compounds in immortalized Rat2 fibroblasts and BP6 rat fibrosarcoma cells in a cell-typespecific manner. We also demonstrated, for the first time, that CA IX is expressed in hypoxic primary rat cardiomyocytes and in immortalized H9c2 cardiomyocytes exposed to physiological or chemical hypoxia and that CA IX expression is increased in hypoxic rat tissues in vivo. Our findings suggest that CA IX expression is not limited to cancer but may be also induced in other pathological situations associated with ischemia or metabolic disturbances leading to activation of the HIF pathway. These data support the view that rats can represent usefulmodel for studies of CA IX as a component of endogenous protection mechanisms associated with hypoxia or perturbed oxygen sensing.
Abstract (in Czech)
CA IX je izoforma aktivní transmembránové karboanhydrázy účastnící se buněčné adheze a kontroly pH. Lidská CA IX je silně indukována hypoxií a je často spojena s různými nádory. V této práci jsme studovali expresi CA IX u potkana pod vlivem chronické hypoxie a jako reakci na léčbu dimethyloxalylglycinem, dimethylester succinátem, diazoxidem a tempolem. Exprese CA IX je regulována hypoxií a látkami, které ji napodobují u immortalizovaných Rat2 fibroblastů a BP6 fibrosarcoma cells potkana. Jako první jsme prokázali, že CA IX je exprimována u hypoxických kardiomyocytů potkana a v immortalizovaných H9c2 kardiomyocytech vystavených fysiologické nebo chemické hypoxii. Zdá se, že CA IX exprese není omezena na nádorové tkáně. Potkan může představovat vhodný model pro studium CA IX jako komponenty endogenních ochranných mechanismů spojených s hypoxií.
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