Detailed Information on Publication Record
2007
Newly Diagnosed Multiple Myeloma Patients with 1q21 Amplification Treated by Autologous Stem Cell Transplantation Have Shorter Progression-Free Survival Interval
NĚMEC, Pavel, Henrieta GREŠLIKOVÁ, Petr KUGLÍK, Hana FILKOVÁ, Romana ZAORALOVÁ et. al.Basic information
Original name
Newly Diagnosed Multiple Myeloma Patients with 1q21 Amplification Treated by Autologous Stem Cell Transplantation Have Shorter Progression-Free Survival Interval
Name in Czech
Nově diagnostikovaní pacienti s amplifikací 1q21 léčeni autologní transplantací mají kratší progression-free interval
Authors
NĚMEC, Pavel (203 Czech Republic), Henrieta GREŠLIKOVÁ (703 Slovakia), Petr KUGLÍK (203 Czech Republic), Hana FILKOVÁ (203 Czech Republic), Romana ZAORALOVÁ (203 Czech Republic), Vladimíra VRANOVÁ (703 Slovakia), Jana SMEJKALOVÁ (203 Czech Republic), Petra VIDLÁKOVÁ (203 Czech Republic), Alexandra OLTOVÁ (203 Czech Republic) and Roman HÁJEK (203 Czech Republic, guarantor)
Edition
Washington DC, USA, Blood 2007, Vol.110(11) Part 2, p. 263B-263B, 1 pp. 2007
Publisher
American Society of Hematology (ASH)
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
Genetics and molecular biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 10.896
RIV identification code
RIV/00216224:14110/07:00019204
Organization unit
Faculty of Medicine
ISSN
UT WoS
000251101102050
Keywords in English
Multiple Myeloma; fluorescence in situ hybridisation; 1q21 Amplification; Autologous stem cell transplantation
Tags
Tags
International impact, Reviewed
Změněno: 19/3/2009 11:03, Mgr. Pavel Němec, Ph.D.
V originále
Amplification of chromosome band 1q21 as well as increased expression of CKS1B gene in this area is a frequently mentioned prognostic factor for patients with multiple myeloma (MM). Total 39 newly diagnosed multiple myeloma patients (median age: 56 years) enrolled in Faculty Hospital Brno, Brno, Czech Republic, were examined for 1q21 amplification status. All patients received 4 cycles of vincristine, adriamycin and dexamethasone (VAD) as induction and one course melphalan 200mg/m2 followed by autologous stem cell transplantation (ASCT). The median follow-up from treatment start was 16.1 (range: 2.2-44.0) months. All the "end-point" intervals and treatment responses were assigned by IMWG criteria. Plasma cells were identified by cytoplasmic light-chain immunofluorescence followed by fluorescence in situ hybridisation (cIg-FISH). Amplification of 1q21 (Amp(1q21)) was assigned utilizing labelled BAC clone (RP11-205M9) DNA probe. Cut-off level for Amp(1q21) was established to 10% of total amount of cells with additional signals detected. Amp(1q21) was found in 41% (16/39) patients. Clinical parameters valid for patients with Amp(1q21) versus patients lacking Amp(1q21) were as follows: overall response rate (ORR) achieved 87.5% (14/16) vs. 91.3% (21/23) patients (p=0.404); overall survival (OS) median was 22.4 months vs. not yet reached (p=0.022); time to progression (TTP) median was 16.1 months vs. not yet reached (p=0.010); progression-free survival (PFS) median was 15.6 months vs. 25.2 months (p=0.023) and duration of response (DOR) median was 15.9 months vs. not yet reached (p=0.048). There were found statistical significant difference in all named "end-point" intervals (OS, TTP, PFS and DOR) between patients with/without Amp(1q21) but not in ORR. In conclusion, patients with Amp(1q21) treated by ASCT have significant shorter PFS median (15.6 months) when compared with patients lacking Amp(1q21) with PFS median 25.2 months (p=0.023). This findings is in accordance with previously published work (Chang et al., 2006).
In Czech
Výsledek pojednává o významu amplifikace 1q21 detekované u pacientů s mnohočetným myelomem léčených autologní transplantací kmenových buněk.
Links
LC06027, research and development project |
| ||
MSM0021622415, plan (intention) |
| ||
NR9317, research and development project |
|