Intracellular clocks and delay-dependent structure of periodic solutions

POKOJSKÁ, Eva and Rachid OUIFKI. Intracellular clocks and delay-dependent structure of periodic solutions. In Max Planck Inst Math in Sciences. Leipzig, 2008.

Basic information

• Original name: Intracellular clocks and delay-dependent structure of periodic solutions
• Authors: POKOJSKÁ, Eva and Rachid OUIFKI.
• Edition: Leipzig, Max Planck Inst Math in Sciences, 2008.

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 10201 Computer sciences, information science, bioinformatics
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Organization unit: Faculty of Medicine
• Tags: International impact

Abstract

Synchronized timings of cellular processes such as metabolic activity, differentiation, division, or cell death result in observation of functional macroscopic tissue-patterns, frequently periodic in time and/or space. Primary regulation is intracellular, originates in adaptive control of gene expression, and can be reproduced by dynamics of simple, delay negative feedback model. We analyze impact of model parameters including nonlinearities or transport/processing delay on stability, bifurcation direction, periodic solutions, and global attractor structure and dimension. Discussed are dynamic classes of transcription regulators, generic 'cellular clock' systems, and their mutual (in)dependence.

Links

• AV0Z60870520, plan (intention): Name: Prostorová a funkční dynamika biologických, ekologických a sociálně-ekonomických systémů v interakci s Globální změnou klimatu
• MSM6007665808, plan (intention): Name: Fyzikální biologie -nové přístupy v biologickém výzkumu