Detailed Information on Publication Record
2008
Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene
KAŇKOVÁ, Kateřina, Marta KALOUSOVA, Miluše HERTLOVÁ, Darja KRUSOVÁ, Jindřich OLŠOVSKÝ et. al.Basic information
Original name
Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene
Name in Czech
Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene
Authors
KAŇKOVÁ, Kateřina (203 Czech Republic, guarantor), Marta KALOUSOVA (203 Czech Republic), Miluše HERTLOVÁ (203 Czech Republic), Darja KRUSOVÁ (203 Czech Republic), Jindřich OLŠOVSKÝ (203 Czech Republic) and Tomáš ZIMA (203 Czech Republic)
Edition
Arch Physiol Biochem, Informa Healthcare, 2008, 1381-3455
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30202 Endocrinology and metabolism
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.841 in 2000
RIV identification code
RIV/00216224:14110/08:00024150
Organization unit
Faculty of Medicine
Keywords in English
diabetes mellitus; soluble RAGE; AGEs; diabetic nephropathy; glomerular filtration rate
Tags
International impact, Reviewed
Změněno: 9/4/2008 19:05, prof. MUDr. Kateřina Kaňková, Ph.D.
V originále
Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2) (P>0.05). In conclusion, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs
In Czech
Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2) (P>0.05). In conclusion, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs
Links
| KJB501620601, research and development project |
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