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@article{753159,
author = {Kaňková, Kateřina and Kalousova, Marta and Hertlová, Miluše and Krusová, Darja and Olšovský, Jindřich and Zima, Tomáš},
article_number = {2},
keywords = {diabetes mellitus; soluble RAGE; AGEs; diabetic nephropathy; glomerular filtration rate},
language = {eng},
issn = {1381-3455},
journal = {Arch Physiol Biochem},
title = {Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene},
volume = {114},
year = {2008}
}
TY - JOUR
ID - 753159
AU - Kaňková, Kateřina - Kalousova, Marta - Hertlová, Miluše - Krusová, Darja - Olšovský, Jindřich - Zima, Tomáš
PY - 2008
TI - Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene
JF - Arch Physiol Biochem
VL - 114
IS - 2
SP - 1-9
EP - 1-9
PB - Informa Healthcare
SN - 13813455
KW - diabetes mellitus
KW - soluble RAGE
KW - AGEs
KW - diabetic nephropathy
KW - glomerular filtration rate
N2 - Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n=94) or DN (n=171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P=0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P<0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P=0.047). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2) (P>0.05). In conclusion, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs
ER -
KAŇKOVÁ, Kateřina, Marta KALOUSOVA, Miluše HERTLOVÁ, Darja KRUSOVÁ, Jindřich OLŠOVSKÝ and Tomáš ZIMA. Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene. \textit{Arch Physiol Biochem}. Informa Healthcare, 2008, vol.~114, No~2, p.~1-9. ISSN~1381-3455.
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