Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds

GRACIA, Tannia, Klára HILSCHEROVÁ, P.D. JONES, J.L. NEWSTED, E.B. HIGLEY, X. ZHANG, Marcus HECKER, M. MURPHY, R.M.K. YU, P.K.S. LAM, R.S.S. WU and John P. GIESY. Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicology and applied pharmacology. 2007, vol. 225, No 2, p. 142-153. ISSN 0041-008X.

Basic information

Original name

Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds

Name in Czech

Modulace exprese steroidogenních enzymů a produkce hormonův buňkách H295R léčivy a dalšími látkami z životního prostředí

Authors

GRACIA, Tannia (840 United States of America), Klára HILSCHEROVÁ (203 Czech Republic, guarantor), P.D. JONES (840 United States of America), J.L. NEWSTED (840 United States of America), E.B. HIGLEY (840 United States of America), X. ZHANG (344 Hong Kong), Marcus HECKER (276 Germany), M. MURPHY (840 United States of America), R.M.K. YU (344 Hong Kong), P.K.S. LAM (344 Hong Kong), R.S.S. WU (344 Hong Kong) and John P. GIESY (840 United States of America)

Edition

Toxicology and applied pharmacology, 2007, 0041-008X

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.846

RIV identification code

RIV/00216224:14310/07:00023833

Organization unit

Faculty of Science

UT WoS

000251332200003

Keywords in English

steroidogenesis; in vitro; hormone production; pharmaceuticals; environmental pollutants; steroidogenic gene expression

Tags

environmental pollutants, hormone production, in vitro, Pharmaceuticals, steroidogenesis, steroidogenic gene expression

Tags

International impact, Reviewed

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Abstract

V originále

The study has shown effects of some commonly used pharmaceuticals with a potential to enter the environment on the hormone production and expression of the key enzymes in steeroidogenesis, documenting thus side effects of these widely used drugs. The tests with binary mixtures have shown different extent of joint action in the mixtures.

In Czech

Studie prokázala vliv vybraných často užívaných léčiv, které mají potenciál dostávat se do prostředí, na produkci hormonů i na expresi klíčových enzymů steroidogeneze, což dokumentuje, že tato léčiva mohou mít vedlejší účinky na průběh steroidogeneze. Testy binárních směsí prokázaly různou míru spolupůsobení léčiv ve směsích.

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Links

MSM0021622412, plan (intention)

Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL) Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)