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@article{755375,
author = {Trávníček, Z. and Popa, I. and Čajan, Michal and Herchel, R. and Marek, Jaromír},
article_location = {Velká Británie},
article_number = {18},
keywords = {Platinum(IV) complexes; Cytotoxicity; 6-Benzylaminopurine; Cytokinins; Bohemine; Roscovitine},
language = {eng},
issn = {0277-5387},
journal = {Polyhedron},
title = {The first platinum(IV) complexes involving aromatic cytokinins or cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+))(2)[PtCl6]Cl-2.4H(2)O},
volume = {26},
year = {2007}
}
TY - JOUR
ID - 755375
AU - Trávníček, Z. - Popa, I. - Čajan, Michal - Herchel, R. - Marek, Jaromír
PY - 2007
TI - The first platinum(IV) complexes involving aromatic cytokinins or cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+))(2)[PtCl6]Cl-2.4H(2)O
JF - Polyhedron
VL - 26
IS - 18
SP - 5271-5282
EP - 5271-5282
PB - Pergamon-Elsevier Science LTD
SN - 02775387
KW - Platinum(IV) complexes
KW - Cytotoxicity
KW - 6-Benzylaminopurine
KW - Cytokinins
KW - Bohemine
KW - Roscovitine
N2 - A series of Pt(IV) complexes with cytokinins or CDK-inhibitors derived from 6-benzylaminopurine (Bap) of the composition [Pt-IV(LH+)Cl-5] (1-14), where LH+ stands for protonated form of the Bap derivative (1-12), Boh = 6-(benzylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurine, bohemine (13) and Ros = 6-(benzylamino)-2-[(1-hydroxymethylpropyl)amino]-9-isopropylpurine, roscovitine (14), have been prepared. They have been fully characterized by microanalysis, conductivity, FT-IR, H-1, C-13, N-15 and Pt-195 NMR and ES+ mass spectroscopy. All of the compounds have been tested in vitro for their cytotoxicity against four human cancer cell lines: malignant melanoma (G361), osteogenic sarcoma (HOS), chronic myelogenous erythroleukemia (K562) and breast adenocarcinoma (MCF7). The molecular structures of two ionic pair compounds (BohH(2)(2+))[PtCl6] center dot H2O (15) and (RosH(2)(2+))(2)[PtCl6]Cl-2 center dot 4H(2)O (16) have been determined by a single crystal X-ray analysis.
ER -
TRÁVNÍČEK, Z., I. POPA, Michal ČAJAN, R. HERCHEL and Jaromír MAREK. The first platinum(IV) complexes involving aromatic cytokinins or cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+))(2)[PtCl6]Cl-2.4H(2)O. \textit{Polyhedron}. Velká Británie: Pergamon-Elsevier Science LTD, 2007, vol.~26, No~18, p.~5271-5282. ISSN~0277-5387.
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