Detailed Information on Publication Record
2008
The association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children
IZAKOVIČOVÁ HOLLÁ, Lydie, Kristína MUSILOVÁ, Jan VOKURKA, Lucie KLAPUŠOVÁ, Pavla PANTŮČKOVÁ et. al.Basic information
Original name
The association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children
Name in Czech
Asociace haplotypů interleukinu-6 (IL-6) s plakem indukovanou gingivitidou u dětí
Authors
IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor), Kristína MUSILOVÁ (203 Czech Republic), Jan VOKURKA (203 Czech Republic), Lucie KLAPUŠOVÁ (203 Czech Republic), Pavla PANTŮČKOVÁ (203 Czech Republic), Martina KUKLETOVÁ (203 Czech Republic), Lubomír KUKLA (203 Czech Republic) and Vladimír ZNOJIL (203 Czech Republic)
Edition
Acta Odontologica Scandinavica, Sweden, Informa Healthcare, 2008, 0001-6357
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Sweden
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.095
RIV identification code
RIV/00216224:14110/08:00025790
Organization unit
Faculty of Medicine
UT WoS
000255441100007
Keywords in English
cytokine; gene; gingivitis; PCR; polymorphism
Tags
Tags
International impact, Reviewed
Změněno: 17/6/2009 11:20, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.
V originále
The proinflammatory cytokine interleukin-6 (IL-6) is a key regulator of the host response to microbial infection and major modulator of extracellular matrix catabolism and bone resorption. The aim of this case-control study was to test differences between children with and without gingivitis in distribution of IL-6 alleles at positions -174, -572, and -597 and their haplotypes. Our results indicate that the three promoter polymorphisms in the IL-6 gene act in a cooperative fashion and suggest that IL-6 haplotypes could play a role in the pathogenesis of gingivitis in Caucasian children.
In Czech
Prozánětlivý cytokin interleukin-6 (IL-6) je klíčovým regulátorem odpovědi organizmu na mikrobiální infekci a hlavním modulátorem katabolizmu extracelulární matrix a resorpce kosti. Cílem této studie bylo analyzovat rozdíly v distribuci IL-6 alel v pozicích -174, -572 a -597 a jejich haplotypů u dětí s gingivitidou a zdravou dásní. Naše výsledky naznačují, že tři promotorové polymorfizmy v genu pro IL-6 se vzájemně doplňují a jejich haplotypy mohou hrát úlohu v patogenezi gingivitidy u dětí.
Links
| NR8394, research and development project |
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| NR9129, research and development project |
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| 1M0528, research and development project |
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