Detailed Information on Publication Record
2008
No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population
BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Martin VAVŘINA et. al.Basic information
Original name
No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population
Name in Czech
Asociace definované variability v genu pro leptin, leptinový receptor, adiponektin, proopiomelanokortin a ghrelin s potravními preferencemi v české populaci
Authors
BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic), Josef TOMANDL (203 Czech Republic, belonging to the institution), Martin FOREJT (203 Czech Republic, belonging to the institution), Martin VAVŘINA (203 Czech Republic, belonging to the institution), Jana KUDĚLKOVÁ (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution)
Edition
Nutritional Neuroscience, Anglie, W. S. Maney and Son, Ltd, 2008, 1028-415X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30202 Endocrinology and metabolism
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.092
RIV identification code
RIV/00216224:14110/08:00033307
Organization unit
Faculty of Medicine
UT WoS
000256999200001
Keywords in English
leptin; leptin receptor; proopiomelanocortin; ghrelin; adiponectin; polymorphism; obesity
Tags
International impact, Reviewed
Změněno: 6/6/2012 08:51, doc. RNDr. Josef Tomandl, Ph.D.
V originále
Background: Previously, it has been reported that mutations in the genes encoding for adipokines may be associated with impaired food intake and may serve as potential obesity biomarkers. Aims: The aim of this study was to investigate the possible associations of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin genes with food preferences in obese and non-obese Czech population and evaluate their potential as the obesity susceptibility genes. Material and methods: Using PCR with following restriction analysis, we studied here 185 volunteers. Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7 day record method. In the group of obese individual, a subset of 34 morbidly obese patients was set off that were available for plasma leptin and soluble leptin receptor levels measurement. Results: None of the examined polymorphisms was associated to anthropometrical or demographic characteristics of the study subjects. The Gln223Arg polymorphism within the leptin receptor gene was significantly associated with lower plasma leptin levels (the RR genotype being more frequent in patients with lower plasma leptin levels, p = 0.001). No associations of the examined polymorphisms with food preferences was observed. Conclusion: Based on our results, the examined polymorphisms in the adipokine genes do not seem to be the major risk factors for obesity development in the Czech population nor significantly affect the food preferences.
In Czech
Na základě předkládaných výsledků se nedomníváme, že sledované polymorfismy v genech pro adipokiny představují významné genetické markery rizika obezity v české populaci nebo faktory významně ovlivňující stravovací preference sledovaných subjektů.
Links
| MSM 141100002, plan (intention) |
|