Detailed Information on Publication Record
2008
CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE
BENEŠ, Petr, Václav VĚTVIČKA and Martin FUSEKBasic information
Original name
CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE
Name in Czech
Katepsin D : mnoho funkcí jediné aspartátové proteázy
Authors
BENEŠ, Petr (203 Czech Republic, guarantor), Václav VĚTVIČKA (203 Czech Republic) and Martin FUSEK (203 Czech Republic)
Edition
Critical Reviews in Oncology/Hematology, ELSEVIER, 2008, 1040-8428
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 4.589
RIV identification code
RIV/00216224:14310/08:00024162
Organization unit
Faculty of Science
UT WoS
000259895900002
Keywords in English
Alzheimer disease; Apoptosis; Atherosclerosis; Aspartic protease; Cancer; Cathepsin D; Knock-out mice; Procathepsin D
Tags
Tags
International impact, Reviewed
Změněno: 25/6/2009 12:19, doc. Mgr. Petr Beneš, Ph.D.
V originále
For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice revealed that CD is not necessary for embryonal development, but it is indispensable for postnatal tissue homeostasis. Mutation that abolishes CD enzymatic activity causes neuronal ceroid lipofuscinosis (NCL) characterized by severe neurodegeneration, developmental regression, visual loss and epilepsy in both animals and humans. In the last decade, however, an increasing number of studies demonstrated that enzymatic function of CD is not restricted solely to acidic milieu of lysosomes with important consequences in regulation of apoptosis. In addition to CD enzymatic activity, it has been shown that apoptosis is also regulated by catalytically inactive mutants of CD which suggests that CD interacts with other important molecules and influences cell signaling. Moreover, procathepsin D (pCD), secreted from cancer cells, acts as a mitogen on both cancer and stromal cells and stimulates their pro-invasive and pro-metastatic properties. Numerous studies found that pCD/CD level represents an independent prognostic factor in a variety of cancers and is therefore considered to be a potential target of anti-cancer therapy. Studies dealing with functions of cathepsin D are complicated by the fact that there are several simultaneous forms of CD in a cell-pCD, intermediate enzymatically active CD and mature heavy and light chain CD. It became evident that these forms may differently regulate the above-mentioned processes. In this article, we review the possible functions of CD and its various forms in cells and organisms during physiological and pathological conditions.
In Czech
Tento přehledný článek shrnuje nejnovější poznatky o úloze různých forem katepsinu D ve fyziologických a patofyziologických procesech na úrovni buňky i celého organismu.
Links
| IAA501630801, research and development project |
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| MSM0021622415, plan (intention) |
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