PECCI, A, E PANZA, N PUJO-MOIX, C KLERSY, F DI BARI, V BOZZI, P GRESELE, S LETHAGEN, C DUFOUR, A GRANATA, Michael DOUBEK, C PECORARO, PA KOIVISTO, PG HELLER, A IOLASCON, P ALVISI, D SCHWABE, E DE CANDIA, B ROCCA, U RUSSO, U RAMENGHI, P NORIS, M SERI, CL BALDUINI a A SAVOIA. Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease. Human Mutation. roč. 29, č. 3, s. 409-417, 8 s. ISSN 1059-7794. 2008. |
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@article{760830, author = {Pecci, A and Panza, E and PujoandMoix, N and Klersy, C and Di Bari, F and Bozzi, V and Gresele, P and Lethagen, S and Dufour, C and Granata, A and Doubek, Michael and Pecoraro, C and Koivisto, PA and Heller, PG and Iolascon, A and Alvisi, P and Schwabe, D and De Candia, E and Rocca, B and Russo, U and Ramenghi, U and Noris, P and Seri, M and Balduini, CL and Savoia, A}, article_number = {3}, keywords = {MYH9-related disease, nonmuscle myosin heavy chain IIA (NMMHC-IIA)}, language = {eng}, issn = {1059-7794}, journal = {Human Mutation}, title = {Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease.}, volume = {29}, year = {2008} }
TY - JOUR ID - 760830 AU - Pecci, A - Panza, E - Pujo-Moix, N - Klersy, C - Di Bari, F - Bozzi, V - Gresele, P - Lethagen, S - Dufour, C - Granata, A - Doubek, Michael - Pecoraro, C - Koivisto, PA - Heller, PG - Iolascon, A - Alvisi, P - Schwabe, D - De Candia, E - Rocca, B - Russo, U - Ramenghi, U - Noris, P - Seri, M - Balduini, CL - Savoia, A PY - 2008 TI - Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease. JF - Human Mutation VL - 29 IS - 3 SP - 409-417 EP - 409-417 SN - 10597794 KW - MYH9-related disease, nonmuscle myosin heavy chain IIA (NMMHC-IIA) N2 - MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in MYH9, the gene for the heavy chain of nonmuscle myosin IIA (NMMHC-IIA). All patients present from birth with macrothrombocytopenia, but in infancy or adult life, some of them develop sensorineural deafness, presenile cataracts, and/or progressive nephritis leading to end-stage renal failure. No consistent correlations have been identified between the 27 different MYH9 mutations identified so far and the variable clinical evolution of the disease. We have evaluated 108 consecutive MYH9-RD patients belonging to 50 unrelated pedigrees. The risk of noncongenital manifestations associated with different genotypes was estimated over time by event-free survival analysis. We demonstrated that all subjects with mutations in the motor domain of NMMHC-IIA present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. We also evaluated the clinical course of patients with mutations in the four most frequently affected residues of NMMHC-IIA (responsible for 70% of MYH9-RD cases). We concluded that mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures. These findings are relevant not only to patients' clinical management but also to the elucidation of the pathogenesis of the disease. ER -
PECCI, A, E PANZA, N PUJO-MOIX, C KLERSY, F DI BARI, V BOZZI, P GRESELE, S LETHAGEN, C DUFOUR, A GRANATA, Michael DOUBEK, C PECORARO, PA KOIVISTO, PG HELLER, A IOLASCON, P ALVISI, D SCHWABE, E DE CANDIA, B ROCCA, U RUSSO, U RAMENGHI, P NORIS, M SERI, CL BALDUINI a A SAVOIA. Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease. \textit{Human Mutation}. roč.~29, č.~3, s.~409-417, 8 s. ISSN~1059-7794. 2008.
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