Impact of Behavioural sensitization to methamphetamine on i.v. self-adminitration of the drug in male and female rat

KUČEROVÁ, Jana, Dagmar VRŠKOVÁ and Alexandra ŠULCOVÁ. Impact of Behavioural sensitization to methamphetamine on i.v. self-adminitration of the drug in male and female rat. European Neuropsychopharmacology. Nice: ECNP, 2008, vol. 18, Suppl. 1, p. 54-55, 1 pp. ISSN 0924-977X.

Basic information

Original name

Impact of Behavioural sensitization to methamphetamine on i.v. self-adminitration of the drug in male and female rat

Name in Czech

Vliv behaviorální sensitizace k metamfetaminu na "i.v. self-adminitration" drogy u potkaních samců a samic

Authors

KUČEROVÁ, Jana, Dagmar VRŠKOVÁ and Alexandra ŠULCOVÁ

Edition

European Neuropsychopharmacology, Nice, ECNP, 2008, 0924-977X

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.661

Organization unit

Faculty of Medicine

UT WoS

000254250500065

Keywords in English

methamphetamine; self-administration; behavioral sensitization; gender differences; rats;

Tags

behavioral sensitization, gender differences, methamphetamine, rats, self-administration

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Abstract

V originále

The female animals were already recorded to respond differently to methamphetamine (MET) abuse than males. This gender dissimilarity may be caused by the influence of estral cycles and different susceptibility to behavioural sensitization. In this study the model of i.v. self-administration of MET (or saline as control) combined with fourteen days (14 D) of intermittent pretreatment with MET (or saline) was used hypothesizing possible influence of behavioral sensitization to the drug on the spontaneous intake in i.v. self-administration sessions was used in male and female rats.

In Czech

V minulosti bylo prokázáno, že samice reagují odlišně na navození metamfetaminové závislosti (MET) než samci. Tento rozdíl může být způsoben vlivem estrálních cyklů a odlišné vulnerability k rozvoji behaviorální sensitizace mezi pohlavími. V této studii byl použit model "i.v. self-administration" MET (nebo fyz. roztoku pro kontrolní skupiny) v kombinaci s dvoutýdenní intermitentní premedikací MET (nebo fyz. roztoku pro kontrolní skupiny). Byl sledován vliv pohlavních hormonů a behaviorální sensitizace k MET na spontánní příjem MET v "i.v. self-administration" modelu.

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Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.