Impact of Behavioural sensitization to methamphetamine on i.v. self-adminitration of the drug in male and female rat

KUČEROVÁ, Jana, Dagmar VRŠKOVÁ and Alexandra ŠULCOVÁ. Impact of Behavioural sensitization to methamphetamine on i.v. self-adminitration of the drug in male and female rat. European Neuropsychopharmacology. Nice: ECNP, 2008, vol. 18, Suppl. 1, p. 54-55, 1 pp. ISSN 0924-977X.

Basic information

• Original name: Impact of Behavioural sensitization to methamphetamine on i.v. self-adminitration of the drug in male and female rat
• Name in Czech: Vliv behaviorální sensitizace k metamfetaminu na "i.v. self-adminitration" drogy u potkaních samců a samic
• Authors: KUČEROVÁ, Jana, Dagmar VRŠKOVÁ and Alexandra ŠULCOVÁ.
• Edition: European Neuropsychopharmacology, Nice, ECNP, 2008, 0924-977X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.661
• Organization unit: Faculty of Medicine
• UT WoS: 000254250500065
• Keywords in English: methamphetamine; self-administration; behavioral sensitization; gender differences; rats
• Tags: behavioral sensitization, gender differences, methamphetamine, rats, self-administration

Abstract

The female animals were already recorded to respond differently to methamphetamine (MET) abuse than males. This gender dissimilarity may be caused by the influence of estral cycles and different susceptibility to behavioural sensitization. In this study the model of i.v. self-administration of MET (or saline as control) combined with fourteen days (14 D) of intermittent pretreatment with MET (or saline) was used hypothesizing possible influence of behavioral sensitization to the drug on the spontaneous intake in i.v. self-administration sessions was used in male and female rats.

Abstract (in Czech)

V minulosti bylo prokázáno, že samice reagují odlišně na navození metamfetaminové závislosti (MET) než samci. Tento rozdíl může být způsoben vlivem estrálních cyklů a odlišné vulnerability k rozvoji behaviorální sensitizace mezi pohlavími. V této studii byl použit model "i.v. self-administration" MET (nebo fyz. roztoku pro kontrolní skupiny) v kombinaci s dvoutýdenní intermitentní premedikací MET (nebo fyz. roztoku pro kontrolní skupiny). Byl sledován vliv pohlavních hormonů a behaviorální sensitizace k MET na spontánní příjem MET v "i.v. self-administration" modelu.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.