TSIKOURIS, Orestis, Tomáš BARTL, Jaromír TOUŠEK, Nikolaos LOUGIAKIS, Tony TITE, Panagiotis MARAKOS, Nicole POULI, Emmanuel MIKROS and Radek MAREK. NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Magnetic Resonance in Chemistry. John Wiley & Sons, 2008, vol. 46, No 7, p. 643-649. ISSN 0749-1581. doi:10.1002/mrc.2226.
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Basic information
Original name NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives
Name in Czech NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives
Authors TSIKOURIS, Orestis (300 Greece), Tomáš BARTL (203 Czech Republic), Jaromír TOUŠEK (203 Czech Republic, belonging to the institution), Nikolaos LOUGIAKIS (300 Greece), Tony TITE (300 Greece), Panagiotis MARAKOS (300 Greece), Nicole POULI (300 Greece), Emmanuel MIKROS (300 Greece) and Radek MAREK (203 Czech Republic, guarantor, belonging to the institution).
Edition Magnetic Resonance in Chemistry, John Wiley & Sons, 2008, 0749-1581.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10403 Physical chemistry
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW DOI: 10.1002/mrc.2226
Impact factor Impact factor: 1.443
RIV identification code RIV/00216224:14310/08:00025874
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1002/mrc.2226
UT WoS 000257052400005
Keywords in English NMR; 1H; 13C; 15N; tautomerism; spin-spin coupling constant; purine; pyrazolo[3.4-c]pyridine; quantum-chemical calculation
Tags 13C, 15N, 1H, NMR, purine, pyrazolo[3.4-c]pyridine, quantum-chemical calculation, spin-spin coupling constant, tautomerism
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Radek Marek, Ph.D., učo 381. Changed: 17/6/2013 14:48.
Substituted pyrazolopyridines are potent inhibitors of phosphodiesterases and cyclin-dependent kinases. In this study, NMR was used to investigate the potential N1-H and N2-H tautomerism of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Six compounds were fully characterized by using 1H, 13C, and 15N chemical shifts and indirect 1H-13C and 1H-15N coupling constants. The 1H NMR spectra were measured over a broad range of temperatures. All of the compounds were shown to exist predominantly in the N1-H tautomeric form. Complementary quantum-chemical calculations of the chemical shieldings and indirect spin-spin couplings support the structural conclusions drawn.
Abstract (in Czech)
Tautomerní NMR studie 5-substituovaných derivátů pyrazolo[3,4-c]pyridinu.
LC06030, research and development projectName: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment
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