TSIKOURIS, Orestis, Tomáš BARTL, Jaromír TOUŠEK, Nikolaos LOUGIAKIS, Tony TITE, Panagiotis MARAKOS, Nicole POULI, Emmanuel MIKROS and Radek MAREK. NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Magnetic Resonance in Chemistry. John Wiley & Sons, 2008, vol. 46, No 7, p. 643-649. ISSN 0749-1581. Available from: https://dx.doi.org/10.1002/mrc.2226. |
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@article{763746, author = {Tsikouris, Orestis and Bartl, Tomáš and Toušek, Jaromír and Lougiakis, Nikolaos and Tite, Tony and Marakos, Panagiotis and Pouli, Nicole and Mikros, Emmanuel and Marek, Radek}, article_number = {7}, doi = {http://dx.doi.org/10.1002/mrc.2226}, keywords = {NMR; 1H; 13C; 15N; tautomerism; spin-spin coupling constant; purine; pyrazolo[3.4-c]pyridine; quantum-chemical calculation}, language = {eng}, issn = {0749-1581}, journal = {Magnetic Resonance in Chemistry}, title = {NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives}, url = {http://dx.doi.org/10.1002/mrc.2226}, volume = {46}, year = {2008} }
TY - JOUR ID - 763746 AU - Tsikouris, Orestis - Bartl, Tomáš - Toušek, Jaromír - Lougiakis, Nikolaos - Tite, Tony - Marakos, Panagiotis - Pouli, Nicole - Mikros, Emmanuel - Marek, Radek PY - 2008 TI - NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives JF - Magnetic Resonance in Chemistry VL - 46 IS - 7 SP - 643-649 EP - 643-649 PB - John Wiley & Sons SN - 07491581 KW - NMR KW - 1H KW - 13C KW - 15N KW - tautomerism KW - spin-spin coupling constant KW - purine KW - pyrazolo[3.4-c]pyridine KW - quantum-chemical calculation UR - http://dx.doi.org/10.1002/mrc.2226 L2 - http://dx.doi.org/10.1002/mrc.2226 N2 - Substituted pyrazolopyridines are potent inhibitors of phosphodiesterases and cyclin-dependent kinases. In this study, NMR was used to investigate the potential N1-H and N2-H tautomerism of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Six compounds were fully characterized by using 1H, 13C, and 15N chemical shifts and indirect 1H-13C and 1H-15N coupling constants. The 1H NMR spectra were measured over a broad range of temperatures. All of the compounds were shown to exist predominantly in the N1-H tautomeric form. Complementary quantum-chemical calculations of the chemical shieldings and indirect spin-spin couplings support the structural conclusions drawn. ER -
TSIKOURIS, Orestis, Tomáš BARTL, Jaromír TOUŠEK, Nikolaos LOUGIAKIS, Tony TITE, Panagiotis MARAKOS, Nicole POULI, Emmanuel MIKROS and Radek MAREK. NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives. \textit{Magnetic Resonance in Chemistry}. John Wiley \&{} Sons, 2008, vol.~46, No~7, p.~643-649. ISSN~0749-1581. Available from: https://dx.doi.org/10.1002/mrc.2226.
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