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@article{764207, author = {Knopfová, Lucia and Šmarda, Jan}, article_location = {Bratislava}, article_number = {4}, keywords = {v-Myb; U937; differentiation; macrophage; phorbol ester; retinoic acid}, language = {eng}, issn = {0028-2685}, journal = {Neoplasma}, title = {v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells}, volume = {55}, year = {2008} }
TY - JOUR ID - 764207 AU - Knopfová, Lucia - Šmarda, Jan PY - 2008 TI - v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells JF - Neoplasma VL - 55 IS - 4 SP - 286-293 EP - 286-293 PB - Slovenská akademie věd SN - 00282685 KW - v-Myb KW - U937 KW - differentiation KW - macrophage KW - phorbol ester KW - retinoic acid N2 - c-myb as well as v-myb oncogene code for transcription factors. They regulate transcription of specific target genes thus controling proliferation, differentiation and apoptosis of hematopoietic cells. Up-regulation of the c-myb expression or rearrangement/amplification of the myb locus are often involved in leukemogenesis. Enforced myb expression blocks differentiation of various leukemic cell lines. Human promonocytes U937 can be induced to differentiate to monocyte/macrophage-like cells using phorbol esters or to granulocytes using retinoic acid. In order to investigate transforming capability of v-myb, we expressed the v-myb oncogene of AMV in U937 cells. We found that v-Myb efficiently suppressed formation of macrophages upon treatment with phorbol ester. Some features of granulocytic differentiation of retinoic-acid-treated U937 cells were affected by the v-Myb protein as well. These results document that v-Myb is significantly involved in control of myeloid differentiation. ER -
KNOPFOVÁ, Lucia and Jan ŠMARDA. v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells. \textit{Neoplasma}. Bratislava: Slovenská akademie věd, 2008, vol.~55, No~4, p.~286-293. ISSN~0028-2685.
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