| FOERSTROVÁ, Michaela, Zuzana JANDUROVÁ, Fernanda MARQUES, Gano LURDES, Přemysl LUBAL, Jakub VANĚK, Petr HERMANN and Isabel SANTOS. Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt). Journal of Inorganic Biochemistry. Amsterdam: Elsevier Science, 2008, vol. 102, No 7, p. 1531-1540. ISSN 0162-0134. |
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@article{769328,
author = {Foerstrová, Michaela and Jandurová, Zuzana and Marques, Fernanda and Lurdes, Gano and Lubal, Přemysl and Vaněk, Jakub and Hermann, Petr and Santos, Isabel},
article_location = {Amsterdam},
article_number = {7},
keywords = {Radiopharmaceuticals; macrocyclic and phosphonate complexes; cyclen derivative; DOTA analogue; lanthanide complexes; radiolanthanides; biodistribution; stability constants; formation and decomplexation kinetics},
language = {eng},
issn = {0162-0134},
journal = {Journal of Inorganic Biochemistry},
title = {Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt)},
volume = {102},
year = {2008}
}
TY - JOUR
ID - 769328
AU - Foerstrová, Michaela - Jandurová, Zuzana - Marques, Fernanda - Lurdes, Gano - Lubal, Přemysl - Vaněk, Jakub - Hermann, Petr - Santos, Isabel
PY - 2008
TI - Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt)
JF - Journal of Inorganic Biochemistry
VL - 102
IS - 7
SP - 1531-1540
EP - 1531-1540
PB - Elsevier Science
SN - 01620134
KW - Radiopharmaceuticals
KW - macrocyclic and phosphonate complexes
KW - cyclen derivative
KW - DOTA analogue
KW - lanthanide complexes
KW - radiolanthanides
KW - biodistribution
KW - stability constants
KW - formation and decomplexation kinetics
N2 - The novel methylphosphonic acid monoethylester (H4dotpOEt) has been synthesized and characterized and their complexes with Sm(III) and Ho(III) ions were studied. Dissociation constants of the ligand are lower than those of H4dota. The stability constants of the Ln(III)-H4dotpOEt complexes are surprisingly much lower that those of H4dota probably due to a lower coordination ability of the phosphonate monoester groups. Acid-assisted decomplexation studies have shown that both complexes are less kinetically inert than the H4dota complexes, but still much more inert than complexes of open-chain ligands. Nevertheless, the synthesis of 153Sm and 166Ho complexes with this ligand led to stable complexes both in vitro and in vivo. A very low binding of these complexes to hydroxyapatite (HA) and calcified tissues was observed confirming the assumption that a fully ionized phosphonate group(s) is necessary for a strong bone affinity. Both complexes show similar behaviour in vivo.
ER -
FOERSTROVÁ, Michaela, Zuzana JANDUROVÁ, Fernanda MARQUES, Gano LURDES, Přemysl LUBAL, Jakub VANĚK, Petr HERMANN and Isabel SANTOS. Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt). \textit{Journal of Inorganic Biochemistry}. Amsterdam: Elsevier Science, 2008, vol.~102, No~7, p.~1531-1540. ISSN~0162-0134.
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