D 2008

Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Anna VAŠKŮ et. al.

Basic information

Original name

Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals

Name in Czech

Dva v populaci četné polymorfismy v genu pro adiponektin jsou asociovány s potravními preferencemi u české extrémně obézní populace

Edition

2008. vyd. Praha, 13th International SHR Symposium, p. 85-85, 1 pp. 2008

Publisher

Institute for Clinical and Experimental Physiology, Prague

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

Genetics and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords in English

adiponectin; polymorphism; gene; obesity; food preferences

Tags

International impact, Reviewed
Změněno: 21/6/2008 22:49, prof. MUDr. Julie Dobrovolná, Ph.D.

Abstract

V originále

Objectives: Considering the pivotal role of adiponectin in white adipose tissue metabolism and signaling, we assessed whether the 45T/G and 94T/G polymorphisms within the adiponectin gene influence the food preferences along with basic anthropometric characteristics in the Czech extremely obese population. Design and Methods: The total of 44 extremely obese subjects were enrolled in the study (BMI 46.03, SD 5.63; % of body fat 50.33, SD 5.13). Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7- day record method. The polymerase chain reaction-restriction fragment length polymorphism (PCR based RFLP) method was used to establish the distribution of allele and genotype frequencies of the 45T/G (exon 2) and 94T/G (exon 2) polymorphisms. ELISA was used to determine plasma levels of leptin and leptin receptor. Results: Both polymorphisms studied were significantly associated with various body size measurements including weight, waist and hip circumference, percentage of body fat and body mass index. Furthermore, the 45T/G was linked to the plasma levels of leptin receptor (beta = -0.36, p = 0.002). A strong effect of 94T/G on the food preferences of the morbidly obese individuals was observed, the 94T/G GG genotypes being significantly associated with the increased protein and carbohydrates intake (beta = -3.2, p = 0.02, beta = -5.5, p = 0.002, respectively). Conclusions: The obtained data well fit into a framework for food intake regulation and could provide possible targets for further nutrigenomical research and intervention focused on the food preferences.

In Czech

Získaná data naznačují silnou asociaci polymorfismů 45 T/G a 94 T/G v exonu 2 genu pro adiponektin s potravními preferencemi extrémně obézní české populace.

Links

MSM 141100002, plan (intention)
Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases