Detailed Information on Publication Record
2008
Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals
BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Anna VAŠKŮ et. al.Basic information
Original name
Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals
Name in Czech
Dva v populaci četné polymorfismy v genu pro adiponektin jsou asociovány s potravními preferencemi u české extrémně obézní populace
Authors
Edition
2008. vyd. Praha, 13th International SHR Symposium, p. 85-85, 1 pp. 2008
Publisher
Institute for Clinical and Experimental Physiology, Prague
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
Genetics and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Organization unit
Faculty of Medicine
Keywords in English
adiponectin; polymorphism; gene; obesity; food preferences
Tags
Tags
International impact, Reviewed
Změněno: 21/6/2008 22:49, prof. MUDr. Julie Dobrovolná, Ph.D.
V originále
Objectives: Considering the pivotal role of adiponectin in white adipose tissue metabolism and signaling, we assessed whether the 45T/G and 94T/G polymorphisms within the adiponectin gene influence the food preferences along with basic anthropometric characteristics in the Czech extremely obese population. Design and Methods: The total of 44 extremely obese subjects were enrolled in the study (BMI 46.03, SD 5.63; % of body fat 50.33, SD 5.13). Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7- day record method. The polymerase chain reaction-restriction fragment length polymorphism (PCR based RFLP) method was used to establish the distribution of allele and genotype frequencies of the 45T/G (exon 2) and 94T/G (exon 2) polymorphisms. ELISA was used to determine plasma levels of leptin and leptin receptor. Results: Both polymorphisms studied were significantly associated with various body size measurements including weight, waist and hip circumference, percentage of body fat and body mass index. Furthermore, the 45T/G was linked to the plasma levels of leptin receptor (beta = -0.36, p = 0.002). A strong effect of 94T/G on the food preferences of the morbidly obese individuals was observed, the 94T/G GG genotypes being significantly associated with the increased protein and carbohydrates intake (beta = -3.2, p = 0.02, beta = -5.5, p = 0.002, respectively). Conclusions: The obtained data well fit into a framework for food intake regulation and could provide possible targets for further nutrigenomical research and intervention focused on the food preferences.
In Czech
Získaná data naznačují silnou asociaci polymorfismů 45 T/G a 94 T/G v exonu 2 genu pro adiponektin s potravními preferencemi extrémně obézní české populace.
Links
MSM 141100002, plan (intention) |
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