BRIDGES, Nikola, Karel ŠLAIS and Eva SYKOVÁ. The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats. Acta Neurobiologiae Experimentalis. Warsaw: Nencki Institute of Experimental Biology, 2008, vol. 68, No 2, p. 131-138. ISSN 0065-1400.
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Basic information
Original name The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats
Name in Czech Vliv chronického podávání kortikosteronu na počet astrocytů v hipokampu: srovnání samců a samic potkana kmene Wistar
Authors BRIDGES, Nikola (826 United Kingdom of Great Britain and Northern Ireland), Karel ŠLAIS (203 Czech Republic, guarantor) and Eva SYKOVÁ (203 Czech Republic).
Edition Acta Neurobiologiae Experimentalis, Warsaw, Nencki Institute of Experimental Biology, 2008, 0065-1400.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Poland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.091
RIV identification code RIV/00216224:14110/08:00026151
Organization unit Faculty of Medicine
UT WoS 000258083200001
Keywords in English astrocyte; corticosterone; hippocampus; rat; sex differences
Tags astrocyte, corticosterone, hippocampus, rat, sex differences
Tags International impact, Reviewed
Changed by Changed by: MUDr. Mgr. Karel Šlais, Ph.D., učo 19989. Changed: 23/6/2009 09:27.
Abstract
In the present study, we investigated the total percentage body weight, hippocampal volume and hippocampal astrocyte numbers following chronic corticosterone treatment in male and female Wistar rats. Males had greater left and right hippocampal volumes overall, but no effect on hippocampal volume was seen after corticosterone treatment. Total body weight was dose-dependently lower in both sexes, but the decrease was more prominent in male rats. Corticosterone treatment dose-dependently increased astrocyte numbers in the CA1 region, but not in the lateral and medial CA3 hippocampal regions. This increase was similar in both male and female rats.
Abstract (in Czech)
Tato práce studovala změny hmotnosti, velikosti hipokampu a počet astrocytů v hipokampu u samců a samic potkana kmene Wistar po dlouhodobém podávání kortikosteronu.
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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